Skeletal Muscle Relaxants Flashcards
NM blockade
Depolarizers
Non depolarizers
Persistent depolarization at end plate
Antagonism at the AcH receptor of the end plate
NM blocking drugs
Spasmolytic drugs
Produce muscle paralysis
Reduce abnormally elevated tone
Larger muscles are more _ to neuromuscular blockade but recover more rapidly
Resistant
Competitive antagonists at skeletal muscle nicotinic ach receptors
Non Depolarizing NM blockers
DOC FOR MYASTHENIA GRAVIS TX
reverse effects with neostigmine
Metabolized by pseudocholinesterase like succinylcholine
Mivacurium
SA Non Depolarizing NM blockers
WOF bronchospasm
Undergoes HOFMANN ELIMINATION to form laudanosine
Atracurium
IA Non Depolarizing NM blockers
Undergoes elimination in BILE
Muscle relaxation potentiated by inhaled anesthetics, aminoglycosides and quinidine
Vecuronium
IA Non Depolarizing NM blockers
WOF hypersensitivity
Reversed by neostigmine And sugammadex
Rocuronium
IA Non Depolarizing NM blockers
WOF ganglion block (hypotension) and recurarization
Relative CI MI
Reversed with neostigmine
Tubocurarine
LA Non Depolarizing NM blockers
Moderate block on cardiac M receptors
EUTHANASIA LETHAL INJECTION STRYCHNINE POISONING
WOF hypertension and recurarization
Reversed with neostigmine
Pancuronium
LA Non Depolarizing NM blockers
Lethal injection
Thiopental
Pancuronium
KCl
Phases of depolarizing blockade
Depolarization
Desensitization
Agonist at Ach-N receptors causing initial twitch then persistent depolarization
WOF ASPIRATION MALIGNANT HYPERTHERMIA
WOF hyperkalemia muscle pain
Metabolized by pseudocholinesterase like mivacurium
Succinylcholine
Depolarizing NM blockers
Early sign of massive calcium release from the sarcoplasmic reticulum of skeletal muscle
Trismus
Malignant Hyperthermia
Cooling and dantrolene
