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Pharmacology > Hyperlipidemia > Flashcards

Hyperlipidemia Flashcards

0
Q

Inc LDL HDL Tg

Inc Chylomicrons

A

Premature atherosclerosis

Premature acute pancreatitis

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1
Q

Lipid lowering drugs

A 
HMG CoA reductase inhibitors
Resins
Sterol absorption blocker
Niacin
Fibrates
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2
Q

Lowers LDL

A

Statins
Resins
Ezetimibe
Niacin

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3
Q

Lowers Tg and VLDL

Raises HDL

A

Niacin

Fibrates

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4
Q

Inhibit hepatic cholesterol synthesis
Stabilization of plaques
WOF Hepatotoxicity and myopathy

A

Simvastatin

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5
Q

Bind bile acids and prevent intestinal reabsorption
Inc TG and VLDL in patients with high TG
Pruritus in cholestasis
WOF constipation, gritty taste, steatorrhea
Contraindicated: diverticulitis

A

Cholestyramine Colesevelam Colestipol

Resins

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6
Q

Sterol absorption blockers

A

Ezetimibe

Sitosterol

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7
Q

Inhibits NPC1L1 transporter that mediates cholesterol transport
Synergistic lowering with statins
WOF hepatotoxicity

A

Ezetimibe

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8
Q

Cholesterol analog

Competitive inhibitor for cholesterol

A

Sitosterol

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9
Q

Reduces VLDL synthesis in the liver
Reduces hormone sensitive lipase activity
Increases VLDL clearance by lipoprotein lipase in capillaries
MOST EFFECTIVE IN INC HDL
WOF hyperuricemia and impaired glucose tolerance
Contraindicated for PUD
Potentiates antihypertensives

A

Niacin

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10
Q

Flushing

A

Vancomycin
Adenosine
Niacin
CCB

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11
Q 
Ligands for PPAR alpha proteins causing inc lipoprotein lipase
Stimulate FA oxidation by liver
Dec expression of apoC-III
Little or no effect on LDL
DOC HYPERTG
WOF cholelithiasis
A

Gemfibrozil Fenofibrate Bezafibrate

Fibrates

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12
Q

Fibrate + resin

A

Cholelithiasis

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13
Q

Statin + resinw

A

Impaired statin absorption

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14
Q

Statin + fribrate

A

Inc risk of myopathy and rhabdomyolysis

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15
Q

High LDL

A

Diet and exercise
Statin
Ezetimibe

16
Q

High VLDL

A

Diet and exercise
Statin
Fibrate

17
Q

High LDL and VLDL

A

Diet and exercise
Statin
Ezetimibe or Niacin

18
Q

High Tg

A

Diet and exercise
Fibrates
Niacin

19
Q

Low HDL

A

Diet and exercise

Niacin

20
Q

High LDL and TG

Low HDL

A

Diet and exercise

Statin + Niacin + Fibrates

21
Q

I Primary hyperchylomicronemia

A

Def LPL or ApoC II
Low fat diet
Niacin / Fibrate

22
Q

IIA Familial hypercholesterolemia

A

Def LDL receptors
Inc LDL
Statin
Niacin and ezetimibe

Pharmacology (33 decks)

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