Hyperlipidemia Flashcards
Inc LDL HDL Tg
Inc Chylomicrons
Premature atherosclerosis
Premature acute pancreatitis
Lipid lowering drugs
HMG CoA reductase inhibitors Resins Sterol absorption blocker Niacin Fibrates
Lowers LDL
Statins
Resins
Ezetimibe
Niacin
Lowers Tg and VLDL
Raises HDL
Niacin
Fibrates
Inhibit hepatic cholesterol synthesis
Stabilization of plaques
WOF Hepatotoxicity and myopathy
Simvastatin
Bind bile acids and prevent intestinal reabsorption
Inc TG and VLDL in patients with high TG
Pruritus in cholestasis
WOF constipation, gritty taste, steatorrhea
Contraindicated: diverticulitis
Cholestyramine Colesevelam Colestipol
Resins
Sterol absorption blockers
Ezetimibe
Sitosterol
Inhibits NPC1L1 transporter that mediates cholesterol transport
Synergistic lowering with statins
WOF hepatotoxicity
Ezetimibe
Cholesterol analog
Competitive inhibitor for cholesterol
Sitosterol
Reduces VLDL synthesis in the liver
Reduces hormone sensitive lipase activity
Increases VLDL clearance by lipoprotein lipase in capillaries
MOST EFFECTIVE IN INC HDL
WOF hyperuricemia and impaired glucose tolerance
Contraindicated for PUD
Potentiates antihypertensives
Niacin
Flushing
Vancomycin
Adenosine
Niacin
CCB
Ligands for PPAR alpha proteins causing inc lipoprotein lipase Stimulate FA oxidation by liver Dec expression of apoC-III Little or no effect on LDL DOC HYPERTG WOF cholelithiasis
Gemfibrozil Fenofibrate Bezafibrate
Fibrates
Fibrate + resin
Cholelithiasis
Statin + resinw
Impaired statin absorption
Statin + fribrate
Inc risk of myopathy and rhabdomyolysis
High LDL
Diet and exercise
Statin
Ezetimibe
High VLDL
Diet and exercise
Statin
Fibrate
High LDL and VLDL
Diet and exercise
Statin
Ezetimibe or Niacin
High Tg
Diet and exercise
Fibrates
Niacin
Low HDL
Diet and exercise
Niacin
High LDL and TG
Low HDL
Diet and exercise
Statin + Niacin + Fibrates
I Primary hyperchylomicronemia
Def LPL or ApoC II
Low fat diet
Niacin / Fibrate
IIA Familial hypercholesterolemia
Def LDL receptors
Inc LDL
Statin
Niacin and ezetimibe
