Opioid Analgesics And Antagonists Flashcards
Opioids
Longest half life
Buprenorphine
Opioids
Shortest half life
Remifentanil
Opioid receptors
Inhibition of respiration
Tolerance
Slowed GI transit
Mabagal hUminga
DelTa
Konstipation
Strong agonist at M receptor
Severe pain post MI
Exerts hemodynamic effects on pulmo circulation
Addiction liability
Morphine
Full agonist
Strong agonist at M receptor
Severe pain
Chronic pain
Breakthrough cancer pain
Fentanyl
Full agonist
Strong agonist at M receptor
Most potent opioid
Ohmefentanyl
Full agonist
Strong agonist at M and K receptors Muscarinic blocking actions DOC SPASMODIC BILIARY AND RENAL PAIN Labor analgesia DOC PANCREATITIS PAIN
Meperidine
Full agonist
Strong agonist at M receptor
Binds NMDA receptors and antagonizes glutamate effects
METHADONE MAINTENANCE THERAPY
NOVEL TX FOR LEUKEMIA
Methadone
Full agonist
Agonist at M and K receptors Inhibits pain at SPINAL AND SUPRASPINAL SITES Cancer pain Neuropathic pain Chronic pain WOF hypogonadism and hearing loss
Hydrocodone
Partial agonist
DEPRESS MEDULLARY COUGH CENTER through sigma receptor stimulation
Dextromorphan
Partial agonist
RESTLESS LEGS SYNDROME
OPIOID WITHDRAWAL
WOF FATAL CARDIOTOXICITY 1C
Propoxyphene
Weak agonist
Strong agonist at K receptors. Weak antagonist at M receptors
BALANCED ANESTHESIA
Opioid and alcohol dependence
Nalbuphine
Mixed agonist-antagonist
OPIOID OVERDOSE
precipitates abstinence syndrome in pts with opioid dependence
Naloxone
Systemic antagonist
FIBROMYALGIA
WOF nausea
CI epilepsy
Tramadol
Dual acting opioid analgesic
Pupillary constriction
Coma
Respiratory depression
Opioid overdose
