Sedative Hypnotic Flashcards
Inc duration of Cl channel opening
Barbiturates
Greater dependence
WOF ACUTE INTERMITTENT PORPHYRIA
Inc frequency of Cl channel opening
Benzodiazepines
Better safety profile
Benzodiazepines
Short midazolam
Intermediate lorazepam
Long diazepam
Acute panic attacks Anesthesia induction for colonoscopy Preoperative sedation Anterograde amnesia WOF REBOUND INSOMNIA/ANXIETY Additive CNS depression with ethanol
Midazolam
SA Benzodiazepine
Seizure disorders Tranquilizer Status epilepticus Anterograde amnesia WOF RESP DEPRESSION Additive CNS. dependence with alcohol
Lorazepam
IA Benzodiazepine
Abnormal sleep pattern resulting from Benzodiazepine use
Dec REM sleep
ALCOHOL WITHDRAWAL
Seizure disorders
Status epilepticus
Tranquilizer
Diazepam
Chlordiazepoxide longest half life
LA Benzodiazepine
Date rape drugs
Alcohol MC
Flunitrazepam
Gamma hydroxybutarate
Slurred speech
Ataxia
Dec mental status
Respiratory depression
Benzodiazepine overdose
FLUMAZENIL
Anesthesia induction
Inc ICP
Thiopental
USA Barbiturate
Insomnia
Preoperative sedation
Pentobarbital
SA/IA Barbiturate
Seizures in pediatric
Hyperbilitubinemia - Gilbert’s
Phenobarbital
LA Barbiturate
Binds selectively to a subgroup of GABA A receptors
INSOMNIA ONLY
Zolpidem
New Hypnotic
Partial agonist at 5HT1A receptors and D2 receptors
GENERALIZED ANXIETY DISORDERS
Buspirone
New Hypnotics
