Parkinsonism

Question 0

Parkinson disease

Answer 0

Tremor
Rigidity
Akinesia
Postural instability

Question 1

Paralysis agitans

Answer 1

Parkinsonism

Question 2

Reversible parkinsonism through intake of

Answer 2

Typical antipsychotics
Reserpine
MPTP

Question 3

DOC PARKINSON’S
WOF ON-OFF PHENOMENA WEARING OFF PHENOMENA
CI PSYCHOSIS
hpn crisis with MAOI

Answer 3

Levodopa dopamine precursor

Carbidopa inhibit dopa decarboxylase

Question 4

Alternating periods of improved mobility and akinesia occurring over a few hours to days during tx

Answer 4

On-Off Phenomena

Question 5

Deterioration of drug effect in between medication doses

Answer 5

Wearing off phenomena

Question 6

Partial agonist at D2 brain receptors
LEVODOPA INTOLERANCE
HYPERPROLACTINEMIA
WOF ERYTHROMELALGIA AND PULMONARY FIBROSIS

Answer 6

Bromocriptine

Question 7

Partial agonist at D3 brain receptors
RESTLESS LEGS SYNDROME
WOF COMPULSIVE GAMBLING HYPERSEXUALITY OVEREATING TENDENCY TO FALL ASLEEP
CI PUD recent MI and psychotic illness

Answer 7

Pramipexole

Question 8

Partial agonist at D3 brain receptors
Antagonist at 5HT and alpha receptors
OFF PERIODS OF PARKINSON’S
Premedicate with trimethobenzamide to prevent SEVERE NAUSEA

Answer 8

Apomorphine

Question 9

MAO TYPE B INHIBITOR

Adjunct

Answer 9

Selegiline

Question 10

COMT inhibitor
WEARING OFF PHENOMENA
WOF sleep disturbance orange urine
WOF NEUROLEPTIC MALIGNANT SYNDROME

Answer 10

Entacapone

Question 11

Antagonizes adenosine
INFLUENZA A
WOF ACUTE TOXIC PSYCHOSIS LIVEDO RETICULARIS
improve bradykjnesia rigidity and tremor

Answer 11

Amantadine

Question 12

Livedo reticularis

Answer 12

Amantadine
Hydroxyurea
Minocycline
Gemcitabine
Quinidine

Question 13

Antimuscarinic Anticholinergic
EXTRAPYRAMIDAL SYMPTOMS
WOF ATROPINE-like effects
Exacerbate tardive dyskinesia from antipsychotic drugs

Answer 13

Benztropine