Gastrointestinal Flashcards
Highly effective in suppressing nocturnal acid secretion but only modest effect on meal stimulated secretion
Cimetidine
H2 receptor antagonist
WOF
MgOH2
AlOH2
Diarrhea
Constipation
DOC PUD
Irreversible blockade of H/K ATPase in active gastric parietal cells
WOF malabsorption infections
Omeprazole
Proton pump inhibitor
Binds to injured tissue and forms protective covering over ulcer
Sucralfate
Inc HCO3 and mucus secretion
Prevention of NSAID induced gastric mucosal injury
Misoprostol
Forms protective coating, direct antimicrobial, enterotoxin sequestration
WOF black stools tongue darkening
Bismuth salicylate
Block D2 receptors
Antiemetic for post operative and chemotherapy vomiting
DOC DM GASTROPARESIS
Metoclopramide
Domperidone does not cross BBB so less toxic
Colloids that absorb water
Constipation
Psyllium
Laxative
Permits water and lipids to penetrate causing stool softening
Constipation
WOF aspiration (lipid pneumonitis) and fat soluble vit malabsorption
Docusate
Obligate inc in fecal fluid
- Hepatic encephalopathy
- preparation for endoscopy
Lactulose
Polyethylene glycol
Stimulant or cathartic
WOF melanosis coli
Bisacodyl
Activates K opioid receptors
Diarrhea >4 yo
Reversed by betanechol
Diphenoxylate
Blocks chemoreceptor trigger zone and 5HT3 receptors
Post chemo/op vomiting
Odansetron
Immunomodulator
Inflammatory bowel disease
Not useful for tx flare ups
Mesalamine
