Antifungal

Question 0

Bunds to ergosterol forming artificial pores
Aspergillus Blastomycrs Candida Cryptococcus Histoplasma Mucor
WOF infusion reactions RTA with mg and k toxicity

Answer 0

Amphotericin B

Polyene

Question 1

Systemic fungal infections

Answer 1

Amphotericin B 
Flucytosine
Ketoconazole
Fluconazole
Itraconazole
Caspofungin

Question 2

Inhibits thymidilate synthase

Cryptococcosis Chromoblastomycosis

Answer 2

Flucytosis

Pyrimidine antimetabolite

Question 3

Inhibit fungal 450 dependent enzymes blocking ergosterol synthesis

Answer 3

Azole

Question 4

Narrow antifungal spectrum

Answer 4

Ketoconazole

Question 5

DOC cryptococcal

Tx and prophy for meningitis

Answer 5

Fluconazole

Question 6

Blastomycosis Sporotrichosis Dermatiphytosis

Answer 6

Itraconazole

Question 7

Inhibits B glucan synthase
Disseminated and mucocutaneous candidiasis
Salvage tx for invasive aspergillosis
WOF flushing

Answer 7

Caspofungin

Question 8

Superficial mycoses

Systemic

Answer 8

Griseofulvin

Terbinafine

Question 9

Interferes with microtubule function to inhibit NA synthesis
Dermatophytosis
Accumulates in keratin

Answer 9

Griseofulvin

Question 10

Inhibit squalene oxidase
Dermatophytosis Onychomycosis
Accumulates in keratin

Answer 10

Terbinafine

Question 11

Superficial fungal infections

Topical

Answer 11

Nystatin

Clotrimazole

Question 12

Polyene
Candidiasis
WOF severe nephrotoxicity
Swish and swallow

Answer 12

Nystatin

Question 13

Azole for pytitiasis versicolor

Answer 13

Clotrimazole