Bronchial Asthma Flashcards
Bronchodilators
SABA
M antagonist
Methylxanthines
Major risk factor
Atopy
SABA
DOC ACUTE ASTHMATIC ATTACKS
WOF tachycardia tremors tolerance tachyphylaxis
Salbutamol
Muscarinic receptor antagonist
Prevent vagal stimulated bronchoconstriction
More effective and less toxic in patients with COPD
Ipatropium
Methylxanthine
Phosphodiesterase inhibition
Prophylactic for nocturnal asthma attacks
Antidote for B blocker overdose
Higher clearance in adolescents and smokers
Theophylline
Methylxanthine used for intermittent claudication
Pentoxifylline
Anti inflammatory
Corticosteroids LABA Mast cell stabilizers Leukotriene antagonists IgE antagonists
No bronchodilator action
Asthma prophylaxis
Prevents Ca influx and stabilizes mast cells
Cromolyn
Nedocromil
Lodoxamide
DOC ASTHMA PROPHYLAXIS
COPD AR
Inhibits phospholipase A2. Reduces COX expression
WOF oropharyngeal candidiasis
Fluticasone
Corticosteroids
Severe refractory asthma
Status asthmaticus
IV HYDROCORTISONE
Lowest systemic steroid toxicity
Ciclesonide
Inhibitor of 5 lipoxygenase
No bronchodilator action
Asthma prophylaxis
WOF Elevation of liver enzymes
Zileuton
Leukotriene synthesis inhibitor
Blocks cysteinyl leukotriene 1 receptor
No bronchodilator action
Asthma prophylaxis
WOF Churg Strauss syndrome
Monteleukast
Anti IgE antibody
Reduce
Prophylaxis of severe refractory asthma
Omalizumab
LABA
Bronchodilation and corticosteroid potentiation
Inc asthma mortality when used alone
Salmeterol
