Histamine, Serotonin And Ergot Alkaloids

Question 0

Excess histamine

Answer 0

Imidazole acetic acid

Question 1

Most important amine autacoids

Answer 1

Histamine

Serotonin

Question 2

Triple Histamine Response

Answer 2

Wheal
Flush
Flare

Question 3

First generation H1 blocker
CNS H1, A and M receptor block
Motion sickness
Hay fever, angioedema

Answer 3

Dipenhydramine

Question 4

Second generation H1 blocker
Peripheral H1 blocker 
Hay fever, angioedema, urticaria
No side effects
Fatal arrhythmias + azoles/erythromycin

Answer 4

Cetitizine

Question 5

H1

H2

Answer 5

Smooth muscle distribution

Stomach, heart, mast cells

Question 6

Reduction of gastric acid secretion
PUD, Zollinger Ellison, GERD
CYP450 inhibitor
WOF gynecomastia

Answer 6

Cimetidine
Ranitidine
Famotidine
Nizatidine

H2 blocker

Question 7

5 HT receptors
1D
2
3
4

Answer 7

Brain
Smooth muscle, platelets
Area postrema (CNS)
ENS

Question 8

5HT1D agonist
DOC ACUTE MIGRAINE
Cluster HA

Answer 8

Sumatriptan

Question 9

5HT3 antagonist

Chemotherapy and post op vomiting

Answer 9

Odansetron

Question 10

5HT3 antagonist

WOF QRS and QT prolongation

Answer 10

Dolasetron

Question 11

5HT3 antagonist
Irritable bowel disease
WOF constipation

Answer 11

Alosetron

Question 12

5HT2 antagonist
Ergot alkaloid: St. Anthony's fire 
Vasoselective
Migrane
Cluster headache

Answer 12

Ergotamine
Methysergide

Antidote: nitroprusside

Question 13

5HT2 antagonist
Ergot alkaloid: St. Anthony's fire 
Uteroselective
Migraine
Postpartum bleeding
WOF uterine spasm and abortion

Answer 13

Ergonovine