Cancer Chemotherapy Flashcards by Christelle Anne Almanon

M phase

Vinblastine
Vincristine
Paclitaxel

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G0 phase

Alkylating agents
Antitumor
Antibiotics
Nitrosureas
Cisplatin

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G2 phase

Bleomycin

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S phase

Cytarabine
6 mercaptopurine
6 thioguanine
Methotrexate
Hydroxyurea
Etoposide

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Rescue therapy

Methotrexate

Leucovorin

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Rescue therapy

Cyclophosphamide

Mesna

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Rescue therapy

Doxorubicin

Dexrazoxane

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Rescue therapy

Cisplatin

Amifostine

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Forms DNA cross links resulting in inhibition of DNA synthesis and function

Cyclophosphamide
Cisplatin
Busulfan
Carmustine
Alkylating agents
Cell cycle non specific

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NHL
CLL
WOF BM suppression and hemorrhagic cystitis

Cyclophosphamide

Alkylating agents

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Advanced colon cancer

WOF Nephro and neurotoxicity

Oxaliplatin
Cisplatin
Alkylating agents

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CML

Spared the bone marrow

Busulfan

Alkylating agents

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Brain tumors
Skin cancer
Highly lipid soluble

Carmustine
Lomustine
Alkylating agents

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Forms hydrogen peroxide and free radicals that cause DNA strand scission

Procarbazine
Dacarbazine
Alkylating agents

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NHL HL

WOF leukemogenic

Procarbazine

Alkylating agents

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NHL HL

WOF phototoxicity flulike syndrome

Dacarbazine

Alkylating agents

Inhibit digydrofolate refuctase
S PHASE
Choriocarcinoma
Primary CNS lymphoma
WOF PROMINENT BM SUPPRESSION

Methotrexate

Antimetabolite

Inhibits de novo purine nucleotide synthesis S PHASE
AML ALL CML
WOF Hepatotoxicity
Inhibited ir allopurinol r febuxostat

6 Mercaptopurine

Antimetabolite purine

Inhibits thymidylate synthase
Colorectal ca
Skin ca

5 FU

Antimetabolite pyrimidine

Inhibits ribonucleotide reductase
AML ALL CML in blast crisis
MOST SPECIFIC FOR S PHASE

Cytarabine

Antimetabolite pyrimidine

Inhibits ribonucleotide reductase

Pancreatic ca

Gemcitabine

Antimetabolite pyrimidine

Prevents microtubule assemby
M PHASE
Acute leukemia
WOF peripheral neuritis and paralytic ileus

Vincristine

Prevents microtubule assemby
M PHASE
Testicular carcinoma
Kaposi’s sarcoma

Vinblastine

Inhibits topoisomerase II

NHL Lung cancer

Etoposide

Teniposide

Inhibits topoisomerase I - SCLC - mets colorectal ca

Topotecan | Irinotecan

Prevents microtubule DISassembly Advanced breast and ovarian ca - wof neutropenia thrombocytopenia - wof neurotoxicity

Paclitaxel | Docetaxel

Intercalates between base pairs Cell cycle nonspecific WOF Dilated cardiomyopathy CHF

Doxorubicin

Intercalating agent causing DNA strand breaks MOST SPECIFIC FOR G2 Testicular ca WOF Pulmonary fibrosis Pneumonitis

Bleomycin

Inhibits DNA dep RNA synthesis Melanoma Wilm's tumor

Actinomycin D

Inhibits TK activity if product of bcr abl oncogene Inhibits ckit TK CML GIST WOF fluid retention

Imatinib

Acts in breast ca cells that overexpress Her2/neu receptor Mets breast ca WOF cardiotoxicity

Trastuzumab

Inhibits binding of VEGF to VEGFR Metastatic colorectal ca NSCLC WOF Hpn arterial thrombosis

Bevacizumab

NHL low grade | Induces complement mediated lysis, direct cytotoxicity and induction of apoptosis

Rituximab

Hairy cell leukemia | T cell lymphomas

Interferon alpha

Depletes serum asparaginase ALL WOF acute pancreatitis

Asparaginase

Differentiation therapy | Only vitamin that can cure acute promyelocytic leukemia

All trans retinoic acid

Hormone responsive breast ca WOF endometrial hyperplasia/ca Prevents osteoporosis and atherosclerosis

Tamoxifen

-Surgical castration - prostate ca Androgen antagonist

Nilutamide | Flutamide

Inhibiting aromatase Breast ca tamoxifen resistant Precocious puberty

Anastrozole