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Pharmacology > Cancer Chemotherapy > Flashcards

Cancer Chemotherapy Flashcards

0
Q

M phase

A

Vinblastine
Vincristine
Paclitaxel

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1
Q

G0 phase

A 
Alkylating agents
Antitumor
Antibiotics
Nitrosureas
Cisplatin
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2
Q

G2 phase

A

Bleomycin

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3
Q

S phase

A 
Cytarabine
6 mercaptopurine
6 thioguanine
Methotrexate
Hydroxyurea
Etoposide
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4
Q

Rescue therapy

Methotrexate

A

Leucovorin

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5
Q

Rescue therapy

Cyclophosphamide

A

Mesna

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6
Q

Rescue therapy

Doxorubicin

A

Dexrazoxane

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7
Q

Rescue therapy

Cisplatin

A

Amifostine

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8
Q

Forms DNA cross links resulting in inhibition of DNA synthesis and function

A 
Cyclophosphamide
Cisplatin
Busulfan
Carmustine
Alkylating agents
Cell cycle non specific
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9
Q

NHL
CLL
WOF BM suppression and hemorrhagic cystitis

A

Cyclophosphamide

Alkylating agents

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10
Q

Advanced colon cancer

WOF Nephro and neurotoxicity

A

Oxaliplatin
Cisplatin
Alkylating agents

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11
Q

CML

Spared the bone marrow

A

Busulfan

Alkylating agents

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12
Q

Brain tumors
Skin cancer
Highly lipid soluble

A

Carmustine
Lomustine
Alkylating agents

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13
Q

Forms hydrogen peroxide and free radicals that cause DNA strand scission

A

Procarbazine
Dacarbazine
Alkylating agents

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14
Q

NHL HL

WOF leukemogenic

A

Procarbazine

Alkylating agents

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15
Q

NHL HL

WOF phototoxicity flulike syndrome

A

Dacarbazine

Alkylating agents

16
Q 
Inhibit digydrofolate refuctase
S PHASE
Choriocarcinoma
Primary CNS lymphoma
WOF PROMINENT BM SUPPRESSION
A

Methotrexate

Antimetabolite

17
Q

Inhibits de novo purine nucleotide synthesis S PHASE
AML ALL CML
WOF Hepatotoxicity
Inhibited ir allopurinol r febuxostat

A

6 Mercaptopurine

Antimetabolite purine

18
Q

Inhibits thymidylate synthase
Colorectal ca
Skin ca

A

5 FU

Antimetabolite pyrimidine

19
Q

Inhibits ribonucleotide reductase
AML ALL CML in blast crisis
MOST SPECIFIC FOR S PHASE

A

Cytarabine

Antimetabolite pyrimidine

20
Q

Inhibits ribonucleotide reductase

Pancreatic ca

A

Gemcitabine

Antimetabolite pyrimidine

21
Q

Prevents microtubule assemby
M PHASE
Acute leukemia
WOF peripheral neuritis and paralytic ileus

A

Vincristine

22
Q

Prevents microtubule assemby
M PHASE
Testicular carcinoma
Kaposi’s sarcoma

A

Vinblastine

23
Q

Inhibits topoisomerase II

NHL Lung cancer

A

Etoposide

Teniposide

24
Q

Inhibits topoisomerase I

  • SCLC
  • mets colorectal ca
A

Topotecan

Irinotecan

25
Q

Prevents microtubule DISassembly
Advanced breast and ovarian ca
- wof neutropenia thrombocytopenia
- wof neurotoxicity

A

Paclitaxel

Docetaxel

26
Q

Intercalates between base pairs
Cell cycle nonspecific
WOF Dilated cardiomyopathy CHF

A

Doxorubicin

27
Q

Intercalating agent causing DNA strand breaks
MOST SPECIFIC FOR G2
Testicular ca
WOF Pulmonary fibrosis Pneumonitis

A

Bleomycin

28
Q

Inhibits DNA dep RNA synthesis
Melanoma
Wilm’s tumor

A

Actinomycin D

29
Q

Inhibits TK activity if product of bcr abl oncogene
Inhibits ckit TK
CML GIST
WOF fluid retention

A

Imatinib

30
Q

Acts in breast ca cells that overexpress Her2/neu receptor
Mets breast ca
WOF cardiotoxicity

A

Trastuzumab

31
Q

Inhibits binding of VEGF to VEGFR
Metastatic colorectal ca
NSCLC
WOF Hpn arterial thrombosis

A

Bevacizumab

32
Q

NHL low grade

Induces complement mediated lysis, direct cytotoxicity and induction of apoptosis

A

Rituximab

33
Q

Hairy cell leukemia

T cell lymphomas

A

Interferon alpha

34
Q

Depletes serum asparaginase
ALL
WOF acute pancreatitis

A

Asparaginase

35
Q

Differentiation therapy

Only vitamin that can cure acute promyelocytic leukemia

A

All trans retinoic acid

36
Q

Hormone responsive breast ca
WOF endometrial hyperplasia/ca
Prevents osteoporosis and atherosclerosis

A

Tamoxifen

37
Q

-Surgical castration
- prostate ca
Androgen antagonist

A

Nilutamide

Flutamide

38
Q

Inhibiting aromatase
Breast ca tamoxifen resistant
Precocious puberty

A

Anastrozole

Pharmacology (33 decks)

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