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Anti Bacterial Flashcards

0
Q

Bacteriostatic

A 
ECSTaTiC
Erythromycin
Clindamycin
Sulfamethoxazole
Trimethoprim
Tetracycline
Chloramphenicol
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1
Q

Bactericidal

A 
Very Finely Proficient At Cell Murder
Vancomycin
Fluoroquinolones
Penicillins
Aminoglycosides
Cephalosporins
Metronidazole
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2
Q

Bacterial Cell Wall Synthesis Inhibitors

A

Penicillins
Cephalosporins

Carbapenem
Monivactam
BLIC
Glycopeptide
Peptide antibiotic
Antimetabolite
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3
Q

Binds to penicillin binding proteins in bacterial membrane. Inhibits transpeptidation. Activates autolytic enzymes
WOF Hypersensitivity and Cross Allergenicity

A

Penicillins

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4
Q 
Streptococcal
Pneumococcal
Meningococcal
Syphilis
Narrow spectrum
A

Pen Vunganga

Pen inGect

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5
Q

Staphylococcal
Resistant to B lactamase
Very narrow spectrum

A

WOF interstitial nephritis methicillin
WOF neutropenia nafcillin
Oxacillin
Cloxacillin

Naf for Staph

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6
Q 
Hemophilus
E coli
Listeria
Proteus
Salmonella
Moraxella
Enterococci
Extended spectrum
A

WOF pseudomembranous colitis and rash ampicillin amp

Amoxicillin oral

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7
Q

Pseudomonas
Enterobacter
Klebsiella

A

Takes Care of Pseudomonas
Ticarcillin has antiplatelet activity
Cabernicillin
Piperacillin

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8
Q 
Surgical prophylaxis
Bone infections
G+
Proteus
E coli
Klebsiella
A 
FADer, help me FAZ my PHarmacology 
Cefadroxil
Cefazolin
Cephapiridin
Cephradine
Cephalexin
1st gen cephalosporins
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9
Q 
Hemophilus
Enterobacter
Neisseria
Proteus
E coli
Klebsiella
Serratia
A 
LORA's FAMily FACtory PROduces FOXY FUR FONes and AZOLE TEa
Loracarbef
Cefamandole
Cefaclor
Cefprozil
Cefoxitin
Cefuroxime
Cefonicid
Cefmetazole
Cefotetan
2nd gen cephalosporin
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10
Q

Inc G-
Pseudomonas
Bacteroides

A 
FEnge PO ng PERA to FIX my TTTTTv
Cefetamet
Cefpodoxin
Cefoperazone
Cefixime
Ceftriaxone
Ceftazidime
Cefotaxime
Ceftizoxime
Ceftibuten
3rd gen cephalosporin
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11
Q

Fourth generation cephalosporin

A

Cefepime

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12
Q

Antipseudomonal cephalosporins

A

Cefoperazone
Ceftazidime
Cefepime

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13
Q

WOF CNS toxicity

A

Meropenem
Imipenem cilastatin
Ertapenem
Carbapenem

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14
Q

No G+ and anaerobe coverage

Penicillin allergy

A

Aztreonam

Monobactam

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15
Q 
Inhibits bacterial B lactamase
Gonococci
Streptococci
E coli
H influenzae
A

Amoxicillin CLAVULANATE
Ampicillin SULBACTAM
Piperacillin TAZOBACTAM

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16
Q

Binding to the D Ala Ala terminus of nascent peptidoglycan

WOF REDMAN SYNDROME

A

Vancomycin

Glycopeotide

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17
Q

Drugs of last resort

A 
I AM your Last Shot at Victory
Imipenem
Amikacin
Meropenem
Linezolid
Streptogramins
Vancomycin
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18
Q

Interferes with last stage in cell wall synthesis
G+
WOF nephrotoxicity
Topical

A

Bacitracin

Peptide antibiotic

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19
Q

Blocks incorporation of D Ala
Drug resistant TB
WOF Neurotoxicity

A

Cycloserine

Antimetabolite

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20
Q

Protein synthesis inhibitors

A

Buy AT 30, CELL at 50
Aminoglycosides
Terracyclines

Chloramphenicol
Erythromycin (Macrolides)
Lincosamides (Clindamycin)
Linezolid
Streptogramins
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21
Q

Meningitis: Strep pneumonia H influenza N meningitidis

WOF Gray baby syndrome

A

Chloramphenicol

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22
Q

DOC CHOLERA
WOF TERATOGEN tooth enamel dysplasia
Do not drink with MILK

A 
Tetracycline
Demeclocycline SIADH
Tigecycline broadest spectrum
Minocycline
Doxycycline Lepto
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23
Q

CAP Pertussis Diphtheria Chlamydia

WOF cholestatic hepatitis QT prolongation

A 
Erythromycin
Azithromycin highest Vd
Clarithromycin
Telithromycin macrolide resistance
Macrolide
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24
Anaerobic infections Endocarditis prophylaxis for penicillin allergy WOF PSEUDOMEMBRANOUS COLITIS
Clindamycin above diaphragm Lincomycin Lincosamide
25
MRSA VRSA VRE | WOF ARTHRALGIA MYALGIA SYNDROME
Quinupristin Dalfopristin | Streptogramin
26
MRSA VRSA VRE Listeria Corynebacteria WOF SEROTONIN SYNDROME
Linezolid | Oxazolidinone
27
As plasma level is inc above MIC, more bacteria killed
Conc dep | Aminoglycosides
28
Directly related to time above MIC
Time dep Penicillins Cephalosporins
29
Post antibiotic effect
Aminoglycosides
30
Narrowest therapeutic window among aminoglycosides | Resistant to enzymes that inactivate other aminoglycosides
Amikacin
31
Aminoglycosides need _ for transport
O2 | Would not work under anaerobic conditions
32
Aminoglycosides | WOF nephrotoxicity ototoxicity teratogen
``` GNATSS Gentamicin Neomicin Amika in Tobramycib Streptomycin Spectinomycin ```
33
Most ototoxic aminoglycoside
Kanamycin | Amikacin
34
Most vestibulotoxic aminoglycoside
Tobramycin | Gentamicin
35
Most nephrotoxic aminoglycoside
Tobramycin | Gentamicin
36
Skin reactions from aminoglycosides
Neomycin and Streptomycin
37
Endocarditis | Ocular infections
Gentamycin | Tobramycin
38
MDR TB
Amikacin
39
TB Tularemia Bubonic plague Brucellosis | WOF Congenital deafness
Streptomycin
40
Bowel preparation for elective surgery Hepatic encephalopathy Topical Reverse NM blockade with Ca gluconate and neostigmine
Neomycin Kanamycin Paromonycin
41
Drug resistant gonorrhea | Gonorrhea in penicillin allergic patients
Spectinomycin
42
Nucleic acid inhibitors
Antifolate | Fluoroquinolones
43
Competitive inhibitors of dihydropteroate synthase
Sulfonamide
44
Inhibitor of dihydrofolate reductase
Trimethoprim
45
BURN INFECTIONS | WOF acute hemolysis in G6PD def
SSD | Mafenide acetate
46
UTI | PCP Toxoplasmosis
TMP-SMX
47
Sulfonamide toxicity
Acute hemolysis in G6PD def | Kernicterus
48
Interferes with topoisomerase II in GN and topoisomerase IV in GP
Fluoroquinolones
49
1st gen fluoroquinolones
Nalidixic acid Cinaxacin Rosoxacin | UTI
50
``` GN Gonococci GP cocci Mycoplasma WOF TENDINITIS AND TENDON RUPTURE ```
Ciprofloxacin Ofloxacin Norfloxacin | 2nd gen fluoroquinolones
51
``` GO Streptococci Enterococci Chalmydia Mycoplasma WOF QT prolongation Engance toxicity of theophylline ```
Levofloxacin Sparfloxacin Grepafloxacin (cardiotoxicity) | 3rd gen fluoroquinolones
52
Broad spectrum including ANAEROBES
Moxifloxacin WOF DM gatifloxacin WOF hepatotoxicity trovafloxacin Gemifloxacin
53
Reactive reduction by ferredoxin forming free radicals disrupting ETC. Anaerobic or mixed intraabdominal infections Pseudomembranous colitis
Metronidazole | Tinidazole
54
Forms multiple reactive intermediates | UTI except Proteus and Pseudomonas
Nitrofurantoin
55
Pulmonary fibrosis
``` BBBAN Me Bleomycin Busulfan Bromocriptine Amiodarone Nitrofurantoin Methotrexate ```
56
``` Inhibits mycolic acid synthesis WOF drug induced lupus Neurotoxicity Hepatitis Most important drug in TB Acetylation in the liver Pyridoxine ```
Isoniazid
57
Inhibits DNA dep RNA polymerase TB Leprosy Prophylaxis for meningo and staph carrier states WOF red orange urine, flu like syndrome, hepatotoxicity Prone to resistance
Rifampicin
58
Inhibits arabinosyl transferases | WOF Visual disturbances
Ethambutol
59
Unknown MOA WOF hepatotoxicity hyperuricemia Most hepatotoxic TB drug Sterilizing agent
Pyrazinamide
60
Inhibition of folic acid synthesis Most active drug against M leprae WOF Methemoglobinemia
Dapsone
61
Binds to guanine bases | Sulfone resistant leprosy
Clofazimine
62
Prophylaxis for atypical mycobacteria
Clarithromycin Azithromycin +/- rifabutin in CD4<50
63
Treatment for atypical mycobacteria
Azithromycin Clarithromycin + ethambutol + rifabutin

Pharmacology (33 decks)

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