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Pharmacology > Anti Bacterial > Flashcards

Anti Bacterial Flashcards

0
Q

Bacteriostatic

A 
ECSTaTiC
Erythromycin
Clindamycin
Sulfamethoxazole
Trimethoprim
Tetracycline
Chloramphenicol
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1
Q

Bactericidal

A 
Very Finely Proficient At Cell Murder
Vancomycin
Fluoroquinolones
Penicillins
Aminoglycosides
Cephalosporins
Metronidazole
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2
Q

Bacterial Cell Wall Synthesis Inhibitors

A

Penicillins
Cephalosporins

Carbapenem
Monivactam
BLIC
Glycopeptide
Peptide antibiotic
Antimetabolite
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3
Q

Binds to penicillin binding proteins in bacterial membrane. Inhibits transpeptidation. Activates autolytic enzymes
WOF Hypersensitivity and Cross Allergenicity

A

Penicillins

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4
Q 
Streptococcal
Pneumococcal
Meningococcal
Syphilis
Narrow spectrum
A

Pen Vunganga

Pen inGect

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5
Q

Staphylococcal
Resistant to B lactamase
Very narrow spectrum

A

WOF interstitial nephritis methicillin
WOF neutropenia nafcillin
Oxacillin
Cloxacillin

Naf for Staph

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6
Q 
Hemophilus
E coli
Listeria
Proteus
Salmonella
Moraxella
Enterococci
Extended spectrum
A

WOF pseudomembranous colitis and rash ampicillin amp

Amoxicillin oral

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7
Q

Pseudomonas
Enterobacter
Klebsiella

A

Takes Care of Pseudomonas
Ticarcillin has antiplatelet activity
Cabernicillin
Piperacillin

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8
Q 
Surgical prophylaxis
Bone infections
G+
Proteus
E coli
Klebsiella
A 
FADer, help me FAZ my PHarmacology 
Cefadroxil
Cefazolin
Cephapiridin
Cephradine
Cephalexin
1st gen cephalosporins
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9
Q 
Hemophilus
Enterobacter
Neisseria
Proteus
E coli
Klebsiella
Serratia
A 
LORA's FAMily FACtory PROduces FOXY FUR FONes and AZOLE TEa
Loracarbef
Cefamandole
Cefaclor
Cefprozil
Cefoxitin
Cefuroxime
Cefonicid
Cefmetazole
Cefotetan
2nd gen cephalosporin
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10
Q

Inc G-
Pseudomonas
Bacteroides

A 
FEnge PO ng PERA to FIX my TTTTTv
Cefetamet
Cefpodoxin
Cefoperazone
Cefixime
Ceftriaxone
Ceftazidime
Cefotaxime
Ceftizoxime
Ceftibuten
3rd gen cephalosporin
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11
Q

Fourth generation cephalosporin

A

Cefepime

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12
Q

Antipseudomonal cephalosporins

A

Cefoperazone
Ceftazidime
Cefepime

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13
Q

WOF CNS toxicity

A

Meropenem
Imipenem cilastatin
Ertapenem
Carbapenem

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14
Q

No G+ and anaerobe coverage

Penicillin allergy

A

Aztreonam

Monobactam

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15
Q 
Inhibits bacterial B lactamase
Gonococci
Streptococci
E coli
H influenzae
A

Amoxicillin CLAVULANATE
Ampicillin SULBACTAM
Piperacillin TAZOBACTAM

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16
Q

Binding to the D Ala Ala terminus of nascent peptidoglycan

WOF REDMAN SYNDROME

A

Vancomycin

Glycopeotide

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17
Q

Drugs of last resort

A 
I AM your Last Shot at Victory
Imipenem
Amikacin
Meropenem
Linezolid
Streptogramins
Vancomycin
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18
Q

Interferes with last stage in cell wall synthesis
G+
WOF nephrotoxicity
Topical

A

Bacitracin

Peptide antibiotic

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19
Q

Blocks incorporation of D Ala
Drug resistant TB
WOF Neurotoxicity

A

Cycloserine

Antimetabolite

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20
Q

Protein synthesis inhibitors

A

Buy AT 30, CELL at 50
Aminoglycosides
Terracyclines

Chloramphenicol
Erythromycin (Macrolides)
Lincosamides (Clindamycin)
Linezolid
Streptogramins
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21
Q

Meningitis: Strep pneumonia H influenza N meningitidis

WOF Gray baby syndrome

A

Chloramphenicol

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22
Q

DOC CHOLERA
WOF TERATOGEN tooth enamel dysplasia
Do not drink with MILK

A 
Tetracycline
Demeclocycline SIADH
Tigecycline broadest spectrum
Minocycline
Doxycycline Lepto
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23
Q

CAP Pertussis Diphtheria Chlamydia

WOF cholestatic hepatitis QT prolongation

A 
Erythromycin
Azithromycin highest Vd
Clarithromycin
Telithromycin macrolide resistance
Macrolide
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24
Q

Anaerobic infections
Endocarditis prophylaxis for penicillin allergy
WOF PSEUDOMEMBRANOUS COLITIS

A

Clindamycin above diaphragm
Lincomycin
Lincosamide

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25
Q

MRSA VRSA VRE

WOF ARTHRALGIA MYALGIA SYNDROME

A

Quinupristin Dalfopristin

Streptogramin

26
Q

MRSA VRSA VRE
Listeria Corynebacteria
WOF SEROTONIN SYNDROME

A

Linezolid

Oxazolidinone

27
Q

As plasma level is inc above MIC, more bacteria killed

A

Conc dep

Aminoglycosides

28
Q

Directly related to time above MIC

A

Time dep
Penicillins
Cephalosporins

29
Q

Post antibiotic effect

A

Aminoglycosides

30
Q

Narrowest therapeutic window among aminoglycosides

Resistant to enzymes that inactivate other aminoglycosides

A

Amikacin

31
Q

Aminoglycosides need _ for transport

A

O2

Would not work under anaerobic conditions

32
Q

Aminoglycosides

WOF nephrotoxicity ototoxicity teratogen

A 
GNATSS
Gentamicin
Neomicin
Amika in
Tobramycib
Streptomycin
Spectinomycin
33
Q

Most ototoxic aminoglycoside

A

Kanamycin

Amikacin

34
Q

Most vestibulotoxic aminoglycoside

A

Tobramycin

Gentamicin

35
Q

Most nephrotoxic aminoglycoside

A

Tobramycin

Gentamicin

36
Q

Skin reactions from aminoglycosides

A

Neomycin and Streptomycin

37
Q

Endocarditis

Ocular infections

A

Gentamycin

Tobramycin

38
Q

MDR TB

A

Amikacin

39
Q

TB Tularemia Bubonic plague Brucellosis

WOF Congenital deafness

A

Streptomycin

40
Q

Bowel preparation for elective surgery
Hepatic encephalopathy
Topical
Reverse NM blockade with Ca gluconate and neostigmine

A

Neomycin
Kanamycin
Paromonycin

41
Q

Drug resistant gonorrhea

Gonorrhea in penicillin allergic patients

A

Spectinomycin

42
Q

Nucleic acid inhibitors

A

Antifolate

Fluoroquinolones

43
Q

Competitive inhibitors of dihydropteroate synthase

A

Sulfonamide

44
Q

Inhibitor of dihydrofolate reductase

A

Trimethoprim

45
Q

BURN INFECTIONS

WOF acute hemolysis in G6PD def

A

SSD

Mafenide acetate

46
Q

UTI

PCP Toxoplasmosis

A

TMP-SMX

47
Q

Sulfonamide toxicity

A

Acute hemolysis in G6PD def

Kernicterus

48
Q

Interferes with topoisomerase II in GN and topoisomerase IV in GP

A

Fluoroquinolones

49
Q

1st gen fluoroquinolones

A

Nalidixic acid Cinaxacin Rosoxacin

UTI

50
Q 
GN
Gonococci
GP cocci
Mycoplasma
WOF TENDINITIS AND TENDON RUPTURE
A

Ciprofloxacin Ofloxacin Norfloxacin

2nd gen fluoroquinolones

51
Q 
GO
Streptococci
Enterococci
Chalmydia Mycoplasma
WOF QT prolongation
Engance toxicity of theophylline
A

Levofloxacin Sparfloxacin Grepafloxacin (cardiotoxicity)

3rd gen fluoroquinolones

52
Q

Broad spectrum including ANAEROBES

A

Moxifloxacin
WOF DM gatifloxacin
WOF hepatotoxicity trovafloxacin
Gemifloxacin

53
Q

Reactive reduction by ferredoxin forming free radicals disrupting ETC. Anaerobic or mixed intraabdominal infections
Pseudomembranous colitis

A

Metronidazole

Tinidazole

54
Q

Forms multiple reactive intermediates

UTI except Proteus and Pseudomonas

A

Nitrofurantoin

55
Q

Pulmonary fibrosis

A 
BBBAN Me
Bleomycin
Busulfan
Bromocriptine
Amiodarone
Nitrofurantoin
Methotrexate
56
Q 
Inhibits mycolic acid synthesis
WOF drug induced lupus Neurotoxicity Hepatitis
Most important drug in TB
Acetylation in the liver
Pyridoxine
A

Isoniazid

57
Q

Inhibits DNA dep RNA polymerase
TB Leprosy
Prophylaxis for meningo and staph carrier states
WOF red orange urine, flu like syndrome, hepatotoxicity
Prone to resistance

A

Rifampicin

58
Q

Inhibits arabinosyl transferases

WOF Visual disturbances

A

Ethambutol

59
Q

Unknown MOA
WOF hepatotoxicity hyperuricemia
Most hepatotoxic TB drug
Sterilizing agent

A

Pyrazinamide

60
Q

Inhibition of folic acid synthesis
Most active drug against M leprae
WOF Methemoglobinemia

A

Dapsone

61
Q

Binds to guanine bases

Sulfone resistant leprosy

A

Clofazimine

62
Q

Prophylaxis for atypical mycobacteria

A

Clarithromycin
Azithromycin
+/- rifabutin in CD4<50

63
Q

Treatment for atypical mycobacteria

A

Azithromycin
Clarithromycin
+ ethambutol
+ rifabutin

Pharmacology (33 decks)

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