Antiarrhythmic Drugs

Question 0

Local anesthetic activity
Phase 0: depolarization
Divided based on AP duration
Depress tissues which are frequently depolarizing or relatively depolarized at rest

Answer 0

1 Na

1A prolong acute MI
1B shorten most selective post MI
1C none refractory arrhythmias

Question 1

Singh Vaughan Williams Classification

Answer 1

1 Na blockers
2 B
3 K
4 Ca

Question 2

1A
INa and some Ik channels
Slowed conduction velocity and pacemaker activity
For atrial and ventricular arrhythmia
WOF Arrhythmia and hypotension
Hyperkalemia exacerbates toxicity

Answer 2

Procainamide
Disopyramide
Quinidine

Question 3

Post MI

WOF drug induced lupus

Answer 3

Procainamide

Question 4

WOF marked antimuscarinic effects

Answer 4

Disopyramide

Question 5

WOF torsades, CINCHONISM, autoimmune ITP

Answer 5

Quinidine

Question 6

Cinchonism

Answer 6

HA
Vertigo
Tinnitus

Question 7

WOF Arrhythmia and hypotension

Answer 7

Class 1A overdose

DOC SODIUM LACTATE

Question 8

1B
No effect on Ik
DOC for vent arrhythmias post MI, digoxin induced arrhythmias
Least cardiotoxic

Answer 8

Lidocaine

Question 9

Agranulocytosis

Answer 9

Clozapine antipsychotic
Cotrimoxazole 
Colchicine
Aminopyrine NSAID
Phenylbutazone NSAID
PTU
Indomethacin
Tocainide 1B

Question 10

1C
INa
DOC for refractory arrhythmias
Contraindicated for post MI arrhythmias

Answer 10

Flecainamide

Question 11

WPW

Answer 11

Procainamide
Amiodarone

1A

Question 12

Class 2
Phase 4
Prolonged PR
Inc QRS duration

Answer 12

B blockers

Question 13

Class 2 and 3 properties

Answer 13

Sotalol

Question 14

DOC for perioperative and thyrotoxic arrhythmias

SVT

Answer 14

Esmolol

Question 15

Longest acting B blocker

Answer 15

Nadolol

Question 16

Low lipid solubility

Answer 16

Atenolol

Question 17

Class 3
Phase 3
Prolong AP duration
Block Ik
Increase QT

Answer 17

Dofetilide
Sotalol
Amiodarone

Question 18

Selective Ik block
Treatment and prophylaxis for a fib
WOF torsades

Answer 18

Dofetilide

Question 19

Ik and B block

WOF torsades

Answer 19

Sotalol

Question 20

Strong Ik block
Group 1 slows conduction velocity
Groups 2 and 4 confer antiarrhythmic activity
Refractory arrhythmias
MOST EFFICACIOUS ANTIARRHYTHMIC
WOF microcrystalline deposits in cornea and skin (toxicity)

Answer 20

Amiodarone

Question 21

Class 4

Inc PR interval

Answer 21

NDHP Ca blockers

Question 22

Inc diastolic Ik of AV node

DOC for paroxysmal SVT and AV nodal arrhythmias

Answer 22

Adenosine

Question 23

Depress ectopic pacemakers cussed by digitalis

Answer 23

K