Antiviral Flashcards
Inhibits fusion between HSV envelope and plasma membrane
Docosanol
DOC HSV
WOF CRYSTALLURIA nephrotoxicity
No activity against HSV strains without thymidine kinase
Acyclovir
DOC for CMV
WOF Leukopenia
No activity against HSV strains without thymidine kinase
Ganciclovir
CMV retinitis
Acyclovir and ganciclovir resistance
Molluscum contagiosum
Active against HSV strains without thymidine kinase
Cifodovir
CMV retinitis Acyclovir resistance HSV in AIDS Active against HSV strains without thymidine kinase WOF hypocalcemia
Forscarnet
HAART
2 NRTI + 1 protease inhibitor
HIV
Prevention of maternal fetal HIV transmission
Inhibit reverse transcriptase
WOF for lactic acidosis with hepatic steatosis
Zidovudine BM suppression Abacavir Hypersensitivity Didanosine Pancreatitis Stavudine Zalcitabine Peripheral neuropathy NRTI with phosphorylation
HIV Inhibit reverse transcriptase Rash increased AST and ALT Teratogenicity Inc chol and Tg
Delavirdine Neviraline
Efavirenz
Etravirine
NNRTI without phosphorylation
HIV GI distress and diarrhea Peripheral neuropathy Rash Hyperbilirubinemia and nephrolothiasis
Atazanavir Fosamprenavir Lopinavir Neldinavir Saquinavir Altazanavir Amprenavir Indinavir Protease inhibitor
Binds to gp41
No cross resistance
Enfuvirtide
Fusion inhibitor
Blocks viral attachment via transmembrane chemokine receptor CCR5
Minimal cross resistance
Maraviroc
CCR5 receptor antagonist
Prevent uncoating by binding to M2 proton channels
Parkinsonism
Influenza A
Amantadine
Inhibits neuraminidase
DOC Influenza A and B
Oseltamivir GI
Zanamivir Bronschospasm in asthmatics
Activate host RNAse
HBV HCV Kaposi
CI autoimmune arrhythmias pregnancy
Interferon a
Inhibit HBV DNA polymerase
Adefovir lactic acidosis nephro and hepatic toxicity
Entecavir HA dizziness fatigue nausea
Lamivudine
