Coagulation Disorders Flashcards
PT
Extrinsic
V VII X prothrombin fibrinogen
PTT
Intrinsic
V VIII IX X XI XII prothrombin fibrinogen
Antiplatelet drugs
Aspirin
Glycoprotein IIB IIIA inhibitors
ADP inhibitors
PDE/Adenosine uptake inhibitors
Prevention of arterial thrombosis
WOF GI toxicity and hypetsensitivity
Reye
Uncoupler
Aspirin
TD 150
LD 500
Samter triad
Asthma
Aspirin sensitivity
Nasal polyps
Aspirin intoxication
Adults
Pedia
Resp Alk with HAGMA
HAGMA
GP IIB IIIA inhibitors
PCI
Abciximab
Eptifibatidr
Tirofiban
Inhibits ADP binding
PCI
Prevention and treatment of arterial thrombosis
Additive effects with aspirin
Clopidogrel
Ticlopidine
Prasugel
GI and hematologic SE more common in which ADP inhibitor
Ticlopidine
Inhibit phosphodiesterase III
Prevent thromboemboic complications of cardiac valve replacement
Secondary stroke prevention with aspirin
WOF HA
Dypiridamole
Phosphodiesterase inhibitor for intermittent claudication
Contra HF
Cilostazol
Indirect thrombin inhibitor Activates antithrombin III Monitor PTT DVT, PE, MI WOF THROMBOCYTOPENIA
Heparin
- Protamine sulfate
ANTICOAGULANT
Indirect thrombin inhibitor which does not require PTT monitoring
Enoxaparin
ANTICOAGULANT
Binds to thrombin’s active site
Percutaenous angioplasty with aspirin
Monitor PTT
No reversal agent
Lepirudin
ANTICOAGULANT
Inhibits vit K dependent factors Monitor PT Chronic anticoagulation except pregnancy WOF SKIN NECROSIS and teratogenesis Rat poison
Warfarin
- slow Vit
- fast FFP
ANTICOAGULANT
Fibrinolytic agent
Acute MI, ischemic stroke, PE
WOF cerebral hemorrhage
Loss of effectiveness on 2nd use
Alteplase
- Aminocaproic acid CI in DIC and GUT bleeding
Contraindications to thrombolysis
Cerebrovascular hemorrhage hx Non hemorrhagic stroke in past year >180/110 during acute presentation Aortic dissection suspicion Active internal bleeding excluding menses
Prevention of hemorrhagic diseases in newborns
Vitamin K1 PHYTONADIONE
Vitamine K2 MENAQUINONE
K3 has no tx use
Increases VIII in mild hemophilia A or von Willebrand
Desmopressin
