Coagulation Disorders

Question 0

PT

Answer 0

Extrinsic

V VII X prothrombin fibrinogen

Question 1

PTT

Answer 1

Intrinsic

V VIII IX X XI XII prothrombin fibrinogen

Question 2

Antiplatelet drugs

Answer 2

Aspirin
Glycoprotein IIB IIIA inhibitors
ADP inhibitors
PDE/Adenosine uptake inhibitors

Question 3

Prevention of arterial thrombosis
WOF GI toxicity and hypetsensitivity
Reye
Uncoupler

Answer 3

Aspirin
TD 150
LD 500

Question 4

Samter triad

Answer 4

Asthma
Aspirin sensitivity
Nasal polyps

Question 5

Aspirin intoxication
Adults
Pedia

Answer 5

Resp Alk with HAGMA

HAGMA

Question 6

GP IIB IIIA inhibitors

PCI

Answer 6

Abciximab
Eptifibatidr
Tirofiban

Question 7

Inhibits ADP binding
PCI
Prevention and treatment of arterial thrombosis
Additive effects with aspirin

Answer 7

Clopidogrel
Ticlopidine
Prasugel

Question 8

GI and hematologic SE more common in which ADP inhibitor

Answer 8

Ticlopidine

Question 9

Inhibit phosphodiesterase III
Prevent thromboemboic complications of cardiac valve replacement
Secondary stroke prevention with aspirin
WOF HA

Answer 9

Dypiridamole

Question 10

Phosphodiesterase inhibitor for intermittent claudication

Contra HF

Answer 10

Cilostazol

Question 11

Indirect thrombin inhibitor
Activates antithrombin III
Monitor PTT
DVT, PE, MI
WOF THROMBOCYTOPENIA

Answer 11

Heparin
- Protamine sulfate

ANTICOAGULANT

Question 12

Indirect thrombin inhibitor which does not require PTT monitoring

Answer 12

Enoxaparin

ANTICOAGULANT

Question 13

Binds to thrombin’s active site
Percutaenous angioplasty with aspirin
Monitor PTT
No reversal agent

Answer 13

Lepirudin

ANTICOAGULANT

Question 14

Inhibits vit K dependent factors
Monitor PT
Chronic anticoagulation except pregnancy
WOF SKIN NECROSIS and teratogenesis
Rat poison

Answer 14

Warfarin

• slow Vit
• fast FFP

ANTICOAGULANT

Question 15

Fibrinolytic agent
Acute MI, ischemic stroke, PE
WOF cerebral hemorrhage
Loss of effectiveness on 2nd use

Answer 15

Alteplase

- Aminocaproic acid CI in DIC and GUT bleeding

Question 16

Contraindications to thrombolysis

Answer 16

Cerebrovascular hemorrhage hx
Non hemorrhagic stroke in past year
>180/110 during acute presentation
Aortic dissection suspicion
Active internal bleeding excluding menses

Question 17

Prevention of hemorrhagic diseases in newborns

Answer 17

Vitamin K1 PHYTONADIONE
Vitamine K2 MENAQUINONE

K3 has no tx use

Question 18

Increases VIII in mild hemophilia A or von Willebrand

Answer 18

Desmopressin