Hypertension Flashcards
Drug classes in hypertension
Diuretics Sympathoplegics Vasodilators Angiotensin antagonists Renin inhibitor
Diuretics
Loop
Thiazide
Inhibit NaCl in distal convoluted tubule
MODERATE diuresis
WOF?
Thiazide HCTZ
Hyper Glycemia Lipidemia Uricemia Calcemia
Hypokalemic metabolic alkalosis
Sulfa allergy
Classes of Sympathoplegics
CNS Sympathetic Outflow Blockers
Ganglion blockers
Nerve terminal blockers
Adrenoreceptor blockers
CNS sympathetic blockers is also known as
A2 agonists
Clonidine
Methyldopa
Ganglion blocker
Hexamethonium
Nicotinic AcH receptor blocker
Nerve terminal blockers
Hypertension (obsolete)
SNARE VMAT blocker
WOF?
Reserpine
Sedation
Severe depression
SUICIDAL IDEATION
Adrenergic blockers
A1 blockers
Beta nonselective blockers
Control BP of pts with pheochromocytoma
Phenoxybenzamine nonselective a blocker
Phentolamine nonselective a blocker
Labetalol nonselective b blocker
Vasodilator classes
Older oral vasodilators
Ca channel blockers
Parenteral vasodilators
Older oral vasodilators
Hydralazine
Minoxidil
Alters intracellular Ca
Relaxes arteriolar smooth muscle
Dec afterload
Pre eclampsia
Hypertension
Heart failure (+ ISDN for BLACKS)
Hydralazine
Drug induced lupus
Hydralazine
Isoniazid
Procainamide
Penicillamine
Opens K channels in vascular smooth muscle
ALOPECIA
WOF HYPERTRICHOSIS
Minoxidil
Calcium blockers
L type channels
Non DHP verapamil CARDIAC
DHP nifedipine amlodipine VASCULAR
SVT
Esmolol
NDHP Ca blockers
WOF gingival hyperplasia, AV block, HF, sinus node depression
Verapamil
Non DHP
WOF pretibial edema, constipation, nausea, flushing, dizziness
Nifedipine
Parenteral vasodilators for HYPERTENSIVE EMERGENCY
Nitroprusside
Fenoldopam
WOF cyanide toxicity
Nitroprusside
Dopamine agonist
WOF hypokalemia
Fenoldopam
Angiotensin antagonists
ACE-i
ARBs
Benefits of angiotensin antagonists
Slows ventricular remodeling and survival in heart failure
Delays progression to diabetic retinopathy
post MI
ACE-I
Renin antagonist
Aliskiren
Malignant Hpn
Parenteral vasodilators + loop diuretics and B blockers
Inhibit NaK2Cl transporter in thick ascending limp of LH
POWERFUL DIURESIS
Pulmonary edema in acute HF
Hypercalcemia and anion overdose
WOF?
Loop Furosemide
Ototoxicity dehydration sulfa allergy
Hypokalemic metabolic alkalosis
Sulfa allergy
