Second Line of Defence - Natural Killer Cells Flashcards
1
Q
What do NK cells search for?
A
Check for viral or cancerous proteins (non-self markers) on body cells
2
Q
Where do NKCs check for self markers on a cell?
A
MHC-1
3
Q
How does a cell display a protein on it’s MHC-1
A
Selects a protein at random
4
Q
How does NK cells cause apoptosis
A
When NK cells punch holes in membrane with perforin and granzymes to signal cell to kill itself orderly.
5
Q
What happens when normal protein is displayed on MHC-1?
A
NK cell does not destroy cell and moves on
6
Q
What happens when viral or cancerous proetin is displayed on MHC-1?
A
NK Cell destroys body cell
7
Q
What happens when no proetin is displayed on MHC-1?
A
NK cell destroys body cell
