Sarcoma Flashcards

1
Q

Epidemiologia e Origem

A
  1. Epidemio < 1% adultos, 12% em crianças
  2. Origem: Tecido mesenquimal
    - 80% partes moles
    - 20% osseo
  3. Fatores desencadeantes
    - Radiaçao ionizante
    - Terapia actinica
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2
Q

Localizaçao

A
  • Maioria: extremidades

- Retroperitonio

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3
Q

Comportamento

A
  • Baixo poder infiltrativo

- Massas volumosas: s/s de compressao, edema, parestesias

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4
Q

Sarcoma mais comum em crianças

A
  • Rabdomiosarcoma
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5
Q

Sarcoma mais comum em adultos

A

Lipossarcoma

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6
Q

Sarcoma mais comum em retroperitonio

A

Lipossarcoma

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7
Q

Dx

A
  1. Extremidades
    - Bx
    - Pequenas: < 5cm: Excisional
    - Maiores : Core needle - agulha grossa
  2. Retroperitonio
    - TC ou RNM abdominal
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8
Q

Riscos da Bx

A
  • Viola capsula tumoral
  • Maior risco de lesao a distancia: disseminaçao celular direta
  • Risco de implantaçao no trajeto da punçao
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9
Q

Estadiamento

A
  • TC: abd, pelve e Tx
  • TNM
  • G: Grau histologico: numero de mitoses: Maior valor PX!
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10
Q

Fatores Px

A
  1. Grau histologico
  2. Tamanho
  3. Localizaçao profunda ( subfascial)
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11
Q

TTo

A
  1. Ressecçao total com margem livre
  2. Amputaçao : raro
  3. RT
    - Irressecabilidade
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12
Q

Recidiva

A
  • Local frequente
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13
Q

Mtts

A
  • Raras

- Pulmao

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14
Q

Tumore desmoide

A
  • Nao sarcoma: Neoplasias de Tecido fibroblastico
  • Sem capacidade de mtts
  • Grande poder de revidiva
  • Polipomatosa adenomatosa familiar
  • Sme de Gardner
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15
Q

Dermatofibrosarcoma Protuberans

A
  • Sarcoma cutaneo
  • Localmente agressivo
  • Translocaçao t(17,22) q(22,13)
  • TTo: resecçao com margem livre (amplas!) ou Imantinib
  • Transformaçao fibrossarcomatosa - pior Px
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