Racemic Epi (Vaponephrine)

Question 1

Racemic Epi Classification

Answer 1

Sympathomimetic

Question 2

Racemic Epi Mechanism

Answer 2

Alpha and Beta agonist (Slightly B2 selective) ->bronchodilation, decreased mucous membrane secretions, relieves subglottic edema.

Question 3

Racemic Epi Pharmacokinetics

Answer 3

Onset: <5m inhaled
Peak: 5-15m
Duration: 1-3h
Half Life: N/A

Question 4

Racemic Epi Indications/Field Use

Answer 4

Croup (Laryngotracheobronchitis)

Question 5

Racemic Epi Contraindications

Answer 5

Epiglottitis

Question 6

Racemic Epi Side Effect/Adverse Reactions

Answer 6

Restlessness, anxiety, dizziness, headache, HTN, tachycardia, N/V

Question 7

Racemic Epi Dose

Answer 7

Pedi:
5mg 1:1000 Epi in 2.5-3.0mL NS, nebulized with oxygen
-or-
0.25-0.75 of 2.25% solution in 2mL NS nebulized with oxygen

Question 8

Racemic Epi Precautions

Answer 8

Rebound effects following clearance of medication.

Question 9

Racemic Epi Drug Interactions

Answer 9

Additive effects with other sympathomimetics