Morphine Sulfate

Question 1

Morphine Classification

Answer 1

Opiate Analgesic

Question 2

Morphine Mechanism

Answer 2

Opiate R agonist -> hyperpolarization of interneurons and decreased release of NT responsible for the transmission of pain impulses to the thalamus and cerebral cortex

Question 3

Morphine Pharmacokinetics

Answer 3

Onset: Immediate IV, 15-30m IM
Peak Effects: 20m IV, 30-60m IM
Duration: 2-7h
Half Life: 1-7h

Question 4

Morphine Indications

Answer 4

Severe pain

Question 5

Morphine Contraindications

Answer 5

• Hypotension

- Significant head trauma with AMS

Question 6

Morphine Side Effects/Adverse Reactions

Answer 6

N/V, Abd cramps, AMS, HA, blurred vision, constricted pupils

Question 7

Morphine Dose

Answer 7

Adult:
0.1mg/kg slow (2mg/min) IV IO IM (max single dose = 10mg) q10m up to 3 total doses
>65y/o: 0.05mg/kg slow (2mg/min) IV IO IM (max single dose = 10mg) q10m up to 3 total doses

Pedi:
0.1mg/kg slow IV IO IM

Question 8

Morphine Precautions

Answer 8

• Causes decreased chemoreceptor responsiveness to increased levels of CO2 -> may lead to respiratory depression
• Caution in pts with hypersensitivity to analogs of morphine

Question 9

Morphine Drug Interactions

Answer 9

Additive effects (CNS depression) when given with antihistamines, antiemetics, sedatives, hypnotics, barbiturates, and EtOH