Midazolam (Versed) Flashcards

1
Q

Midazolam Classification

A

Anticonvulsant/Sedative/Hypnotic/Benzodiazepine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Midazolam Mechanism

A

Positive allosteric modulator for GABA receptors -> Binds to benzodiazepine receptor site on Cl- channels and potentiates binding and effects of GABA -> increased intracellular Cl- concentrations -> hyperpolarization

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Midazolam Pharmacokinetics

A

Onset: 3-5min IV, 15min IM
Peak: 20-60min
Duration: <2h IV, 1-6h IM
Half Life: 1-4h

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Midazolam Indications

A
  • Seizure
  • Premed for cardioversion or TCP
  • Post intubation sedation
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Midazolam Contraindications

A

Hypotension

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Midazolam Side Effects/Adverse Reactions

A

Hypotension, drowsiness, amnesia, respiratory depression, blurred vision, AMS, N/V

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Midazolam Dose

A

Adult:
Premed: 2-5mg slow IV IO IM
Sedation: 2-5mg q5-10min slow IV IO
Seizure: 2-6mg IV; 10mg IM IN

Pedi:
0.2mg/kg slow IV (max 10mg)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Midazolam Precautions

A
  • May cause CNS depression and respiratory depression

- Caution with acute EtOH intoxication

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Midazolam Drug Interactions

A

Additive effects with CNS depressants and EtOH

How well did you know this?
1
Not at all
2
3
4
5
Perfectly