Albuterol Sulfate (Proventil HFA, ProAir HFA)

Question 1

Albuterol Classification

Answer 1

Sympathomimetic/Sympathetic agonist (B2 selective)

Question 2

Albuterol Mechanism

Answer 2

B2 agonist -> promotes sympathetic stimulation of bronchial SMC, reducing interaction between actin and myosin causing SM relaxation -> bronchodilation

Question 3

Albuterol Pharmacokinetics

Answer 3

Onset: 5-15m
Peak Effects: 1-1.5h
Duration: 3-6h
Half Life: <3h

Question 4

Albuterol Indications

Answer 4

• Reversible bronchospasm associated with COPD and asthma

- Wheezing associated with allergic reaction/anaphylaxis

Question 5

Albuterol Contraindications

Answer 5

• Symptomatic tachycardia

- Hypersensitivity

Question 6

Albuterol Side Effects/Adverse Reactions

Answer 6

Anxiety, HA, palpitations, sweating, dizziness, HTN, nervousness, tremor, CP, N/V, dysrhythmias

Question 7

Albuterol Dose

Answer 7

Adult & Pedi:

small volume nebulizer: 2.5mg in 2.5cc NS, nebulized with O2 at 8lpm

Question 8

Albuterol Precautions

Answer 8

• May worsen cardiac asthma and precipitate dysrhythmias

- Consider 12-lead EKG in pts with associated CP

Question 9

Albuterol Drug Interactions

Answer 9

• Side effects may increase with other sympathetic agonists
• Beta blockers may blunt effects of this drug
• MAOI and TCA may potentiate CV effects