Haloperidol (Haldol)

Question 1

Haloperidol Classification

Answer 1

Butyrophenone Antipsycotic/Neuroleptic

Question 2

Haloperidol Mechanism

Answer 2

Mesolimbic D1/D2 antagonist -> depresses release of hypothalamic and Hypophyseal hormones; depresses the reticular activating system, thus affecting basal metabolism, body temp, wakefulness, vasomotor tone, and emesis

Question 3

Haloperidol Pharmacokinetics

Answer 3

Onset: 30-45m
Peak: 10-20m
Duration: Varies
Half Life: 3-35h

Question 4

Haloperidol Indications/Field Use

Answer 4

Acute psycotic episode

Question 5

Haloperidol Contraindications

Answer 5

• CNS depression

- Agitation secondary to shock or hypoxia

Question 6

Haloperidol Side Effects/Adverse Reactions

Answer 6

EPS, insomnia, restlessness, drowsiness, seizures, dry mouth, constipation, respiratory depression, tachycardia, hypotension, prolonged QT syndrome, Torsades

Question 7

Haloperidol Dose

Answer 7

Adult:
5mg IM q4-8h PRN
Pedi:
1-3mg IM q4-8h PRN, max 0.15mg/kg/day

Question 8

Haloperidol Precautions

Answer 8

• May impair physical and mental abilities
• May cause orthostatic hypotension
• May cause EPS or dystonic reaction

Question 9

Haloperidol Drug Interactions

Answer 9

• Caution in patients taking lithium, may cause encephalopathic syndrome (irreversible brain damage)
• May increase chance of hypotension when taken with antihypertensives
• Additive effects with depressants and other anti-psycotics - increased CNS depression