Aspirin, Acetylsalicylic Acid, ASA (Bayer)

Question 1

ASA Classification

Answer 1

Platelet aggregation inhibitor/Salicylate/Anti-inflammatory

Question 2

ASA Mechanism

Answer 2

• Inhibits platelet aggregation by blocking the formation of thromboxane A2 -> Thromboxane A2 causes platelet aggregation and arterial constriction
• COX inhibitor -> inhibits prostaglandin synthesis and decreases spread of inflammation

Question 3

ASA Pharmacokinetics

Answer 3

Onset: 5-30m
Peak Effects: 15-120m
Duration: 1-4h
Half Life: 15-20m

Question 4

ASA Indications

Answer 4

CP suggestive of AMI/ACS

Question 5

ASA Contraindications

Answer 5

• Active GI bleeding

- Hypersensitivity

Question 6

ASA Side Effects/Adverse Reactions

Answer 6

GI bleeding, wheezing, N/V, heartburn, prolonged bleeding

Question 7

ASA Dose

Answer 7

Adult:
160-325mg PO; 81mg baby aspirin tablets preferred as they can be chewed or swallowed

Pedi:
Not recommended

Question 8

ASA Precautions

Answer 8

Can Cause GI upset

Question 9

ASA Drug Interactions

Answer 9

• Enhanced side effects with other anti-inflammatory agents

- Decreased absorption with concurrent antacid administration