Diltiazem (Cardizem) Flashcards
1
Q
Diltiazem Classification
A
Ca2+ channel blocker
2
Q
Diltiazem Mechanism
A
- SMC- Ca2+ channel blocker -> inhibits Ca2+ entry and subsequent interaction between actin and myosin in SMC -> SM relaxation and dilation of blood vessels
- Cardiac - Ca2+ channel blocker -> negative inotropy, chronotropy, and dromotropy
3
Q
Diltiazem Pharmacokinetics
A
Onset: 3min
Peak Effects: 7min
Duration: 1-3h
Half Life: 2h
4
Q
Diltiazem Indications
A
- Rapid ventricular rates (>150bpm) associated with A-fib, A-flutter
- PSVT refractory to adenosine
5
Q
Diltiazem Contraindications
A
- Hypotension
- Decompensated cardiogenic shock
- Ventricular tachycardia
- WPW
6
Q
Diltiazem Side Effects/Adverse Reactions
A
N/V, HA, dizziness, bradycardia, heart block, hypotension
7
Q
Diltiazem Dose
A
Adult:
1st dose: 0.25mg/kg slow IV IO over 2 min (usual 15-20mg)
2nd dose: 0.35 mg/kg
Maintenance: 5-15mg/kg
Pedi:
Not for Pediatrics
8
Q
Diltiazem Precautions
A
Must be discarded after 1 month refrigeration
9
Q
Diltiazem Drug Interactions
A
Do NOT give to pts receiving IV Beta blockers; will increase risk of profound bradycardia
