Amyl Nitrate Flashcards

1
Q

Amyl Classification

A

Antidote/Nitrate Vasodilator

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2
Q

Amyl Mechanism

A

Short acting vasodilator and SMC relaxant that oxidizes hemoglobin to become methemoglobin, which forms a non-toxic complex with the cyanide ion to form cyanomethemoglobin, which can be enzymatically degraded.

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3
Q

Amyl Pharmacokinetics

A

Onset: 10-30s
Peak Effects: 30s
Duration: 3-5m
Half Life: N/A

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4
Q

Amyl Indications/Field Use

A

Cyanide poisoning

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5
Q

Amyl Contraindications

A

None

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6
Q

Amyl Side Effects/Adverse Reactions

A

HA, dizziness, weakness, flushing, cold sweats, tachycardia, syncope, orthostatic hypotension, N/V

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7
Q

Amyl Dose

A

Adult & Pedi:0.3mL ampule crushed, inhaled over 15-30 seconds, q1m until sodium nitrate infusion is available

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8
Q

Amyl Precautions

A
  • May be a medication of abuse, should be stored in secure place with narcotics
  • Smells like dirty, sweaty socks
  • Ensure patient is sitting prior to administration, hypotension and syncope may be sudden
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9
Q

Amyl Drug Interactions

A

Hypotension potentiated by antihypertensives, Beta-Blockers, and certain antiemetics (phenothiazines).

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