Naloxone (Narcan)

Question 1

Naloxone Classification

Answer 1

Opiate antagonist/Antidote

Question 2

Naloxone Mechanism

Answer 2

Competitive opiate R antagonist -> displaces narcotic molecules, has greater affinity for R site, but shorter duration

Question 3

Naloxone Pharmacokinetics

Answer 3

Onset: <2m IV, 2-10m IM
Duration: 20-120m
Half Life: 60-90m

Question 4

Naloxone Indications/Field Use

Answer 4

• Partial/Complete reversal of respiratory depression caused by narcotic/opiates
• Coma of unknown origin
• R/O narcotic involvement in polypharmacy overdose prior to RSI

Question 5

Naloxone Contraindications

Answer 5

Hypersensitivity

Question 6

Naloxone Side Effects/Adverse Reactions

Answer 6

Hypotension, hypertension, ventricular dysrhythmias, N/V, seizures

Question 7

Naloxone Dose

Answer 7

Adult:
0.4-2mg slow IV/IO q2-3m, 2mg IN (1mg/nare), 2mg IM - until respiratory status improves
Pedi:
0.1mg/kg IM, IV, IO, IN - max 2mg/dose

Question 8

Naloxone Precautions

Answer 8

Caution in patient potentially dependent on narcotics, may induce withdrawal - including newborn infants with addicted mothers

Question 9

Naloxone Drug Interactions

Answer 9

May induce withdrawal on narcotic dependent patient.