Dopamine

Question 0

Dopamine mechanism

Answer 0

Alpha1 agonist -> 2nd messenger release of ca2+ in vsmc -> peripheral vasoconstriction -> increased svr -> increased BP

Beta1 agonist -> increased intracellular ca2+ in cardiac cells -> positive inotropy, chronotropy, dromotropy

Question 1

Dopamine classification

Answer 1

Sympathetic agonist/sympathomimetic/catecholamine

Question 2

Dopamine pharmacokinetics

Answer 2

Onset: <10min

Half life: 2min

Question 3

Dopamine indications

Answer 3

• cardiogenic shock
• symptomatic bradycardia
• septic shock following fluid resuscitation

Question 4

Dopamine contraindications

Answer 4

Hypovolemia

Question 5

Dopamine side effects/adverse reactions

Answer 5

Cp, ha, n/v, nervousness, dysrhythmias, palpitations, dyspnea

Question 6

Dopamine dose

Answer 6

Adult:
Low: 2-5mcg/kg/min IV io infusion -> causes increased blood flow to mesentary and renal (gut)
Mid: 5-10 mcg/kg/min IV io infusion -> stimulates beta effects
High: 10-20mcg/kg/min IV io infusion -> stimulates alpha effects

Pedi: 2-20 mcg/kg/min IV io infusion

Question 7

Dopamine precautions

Answer 7

Must be kept out of direct sunlight

Question 8

Dopamine drug interactions

Answer 8

• deactivated by alkaline solutions

- hypotension with Dilantin