Olanzapine (Zyprexa) Flashcards

1
Q

Olanzapine Classification

A

Antipsychotic

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2
Q

Olanzapine Mechanism

A

SSRI, NE reuptake inhibitor -> antipsychotic and anticholinergic effects

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3
Q

Olanzapine Pharmacokinetics

A

Onset: <30m
Peak: 6h
Duration: Varies
Half Life: 21-54h

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4
Q

Olanzapine Indications/Field Use

A
  • Acute psychosis or agitation

- Alzheimer’s disease

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5
Q

Olanzapine Contraindications

A

Hypersensitivity

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6
Q

Olanzapine Dose

A

Adult:
10mg IM
Pedi:
Not established

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7
Q

Olanzapine Side Effects/Adverse Reactions

A

Myalgia, somnolence, dizziness, tremor, tachycardia, postural hypotension, nausea, dry mouth

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8
Q

Olanzapine Precautions

A
  • Caution in pt with CV disease, predisposition for hypotension and Parkinson’s disease
  • Must be reconstituted in 3mL sterile water prior to administration
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9
Q

Olanzapine Drug Interactions

A

Potentiates hypotensive effects of antihypertensives

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