Methylprednisolone (SoluMedrol)

Question 1

Methylprednisolone Classification

Answer 1

Corticosteroid/Anti-inflammatory

Question 2

Methylprednisolone Mechanism

Answer 2

Diffuses across cell membranes of various cells in all tissues, binds to DNA, regulates gene expression and increases synthesis of proteins and enzymes that inhibit inflammatory agents (cytokines, interleukin, interferon); inhibits synthesis of pro-inflammatory enzymes; is and immunosuppressant

Question 3

Methylprednisolone Pharmacokinetics

Answer 3

Onset: 2-6h
Peak Effects: 4-8d
Duration: 1-5weeks
Half Life: 3.5h

Question 4

Methylprednisolone Indications

Answer 4

• Asthma, COPD

- Allergic reaction/Anaphylaxis

Question 5

Methylprednisolone Contraindications

Answer 5

None in EMS

Question 6

Methylprednisolone Side Effects/Adverse Reactions

Answer 6

Fluid retention, CHF, HTN, Abd distention, vertigo, HA, nausea, malaise, hiccups

Question 7

Methylprednisolone Dose

Answer 7

Adult:
Asthma/Anaphylaxis: 125mg slow IV IO

Pedi:
Asthma/Anaphylaxis: 2mg/kg slow IV IO max=125mg

Question 8

Methylprednisolone Precautions

Answer 8

Give only one dose prehospitally; long term steroid use can cause GI bleeding, prolonged wound healing, and suppression of adrenocortical steroids

Question 9

Methylprednisolone Drug Interactions

Answer 9

• Lasix and thiazied diuretics increase K+ excretion

- Decreased effect with phenytoin, phenobarbital, and rifampin due to increased metabolism of steroids