physiology week 11 +12 Flashcards
How does Body fluids remain constant
Body fluids remain constant due to a balance between fluid intake and output
Name sources of daily water intake
- Ingested water(from liquids+ food)
-Synthesized water
Name sources of daily water loss
Insensible water loss:
skin
Respitatory tract
-sweat
-Feces
-Kidneys
What is the role of the kidneys
- It adjusts water and electrolyte excretion to balance intake and compensate for losses
- The regulate electrolytes like Na,cl,k
What is body fluid divided into
-ICF
-ECF
What does ECF contain
- Transcelluler fluid
-Interstitial fluid
-Blood plasma
What does Transcellular fluid contain
- Cerebrospinal fluid
and fluid in the :
-Synovial
-peritoneal
-pericadial
intraocular spacesssss
What factors does total body water depend on
- Age
-Sex - Fat percentage
What is extracellular fluid subdivided into
- interstitial fluid
- plasma
Name the cations and the amounts that ECF contains
Large amounts of Na+,
Small amounts of k+,Ca2+,Mg2+
Name the Anions and the amounts in which the ECF contains
- Large amounts of Cl- and bicarbonate ions with small amounts of phosphate and organic acids
Explain the similarity between plasma and interstitial fluid
They have a similar ionic concentration due to highly permeable capillary membranes
Explain the differences between plasma and interstitial fluid
- Plasma has a higher concentration of protons due to low permeability of capillaries to proteins
What is the Donna Effect
- It is that Plasma has slightly higher cations than interstitial fluid because plasma proteins bind cations and repel anions
How is the ICF separated from the ECF
- By a cell membrane that is permeable to water but not to most electrolytes
Name the cations that ICF contains and the amounts
- High amounts of k+ and moderate Mg2+
Name the anions that the ICF contains and the amounts
-ICF contains high amounts of phosphate and sulphate ions
- Low amounts of chloride and sodium Concentrations
How is the body fluid compartment volumes measured
- Indicator-dlution principle
Explain the method of the Indicator-Diltuion principle
- Inject a known amount of indicator into the compartment
- Allow the substanc to mix evenly throughout the compartment
- Analayze the final concentration of the indicator in the fluid sample
What does the calculation formula for indicator dilution principle :VolumeB=
ConcentrationB
VolumeA ×ConcentrationA
Require knowing for the equation to be used
Requires knowing:
-The total amount of indicator injected
- Final concentration of the indicator in the compartment
What conditions is needed for the indicator-dilution method to be accurate
- Indicator must diperse evenly throughout the compartment
-Indicator must remain restricted to the compartment being measured - Indicator should not be metabloized or excreted
What does measurement of Total body water use
- Uses substaces like radioactive water or antipyrine
What does measurement of Extracellular fluid volume use
- Substances such as radiocative sodium, radioactive chloride
What does the measurement of plasma volume use
- Using substances that remain in the vascular system