Biochemistry week 15

Question 1

Tryptophan metabolism results in (3)

Answer 1

• Niacin, serotonin , melatonin

Question 2

Histidine metabolism results in

Answer 2

• Histamine

Question 3

Glycine metabolism results in

Answer 3

• Heme

Question 4

Arginine metabolism results in (3)

Answer 4

Creatine , urea , nitric oxide

Question 5

Glutamate metabolism results in

Answer 5

GABA

Question 6

What are the 20 amino acids broken down into

Answer 6

• Intermediates in carbohydrates and lipid metabloism

Question 7

Name the amino acid that form ocaloacetate

Answer 7

• Aspartate through transamination

Question 8

Name the amino acids that form a ketoglutarate via glutamate(4)

Answer 8

• Glutamine
  -Proline
  -Arginine
  -Histidine

Question 9

Name the amino acids that form pyruvate(5)

Answer 9

• Alanine, serine,Glycine,Cysteine, Threonine

Question 10

Name the amino acids that form fumarate and the process

Answer 10

• Phenylalanine and Tyrosine
• PAH (phenylalanine hydroxylase ) catalyzes phenylalanine hydroxylation producing tyrosine

Question 11

What type of amino acids are Phenylalanine and Tyrosine

Answer 11

• Glucogenic and ketogenix

Question 12

What is PhenylKetonuria caused by

Answer 12

-Deficiency of phenylalanine hydroxylase activity due to:
-Defective enzyme
-Deficient BH4 cofactor

Question 13

Name the three Elevated Phenylalanine metabolites

Answer 13

-Phenylpyruvate ,
-phenylacetate, phenyllactate

Question 14

What are the effects of Phenylketonuria on the central nervous system

Answer 14

-Severe intellectual disability
-Developmental delay, -microcephaly,
-seizures

Question 15

What are the effetcs of Phenylketonuria in relation to hypopigmentation

Answer 15

Leads to :
-Fair hair, light skin, blue eyes due to decreased melanin synthesis

Question 16

What is used to detect elevated phenyalanine blood levels

Answer 16

• Laboratory testing