Pain and Anxiety Week 3 Flashcards
What is the mechanism of action for topical anesthetics?
- Blocks nerve conduction at mucous membrane surfaces
- Decreases Na+ permeability = decreases depolarization = blocks nerve impulse
(MOA is similar to injectable LAs)
What are the different forms of topical anesthetics?
Gel
Ointment
Metered and unmetered sprays
Cream
Liquid
Lozenges
What is the range of effective concentrations for topical anesthetics? What does this depend on?
0.2% - 20%, depends on form
What is the choice of method of delivery for topical anesthetic based on?
Each individual patient
Which topical anesthetic is associated with methemoglobinemia?
Benzocaine sprays
(recall that injectable procaine has the same issue)
Why do we need the site to be dried with gauze or sponge before we apply the topical anesthetic?
dryer site = will absorb the anesthetic better
(won’t get washed away by saliva)
How long should topical anesthetic be placed at site?
1-2 mins
What is the tissue depth of topical anesthetic?
2-3 mm
What are 3 common topical anesthetics used in dentistry?
Benzocaine
Lidocaine
Combination of Benzocaine + Butamben + Tetracaine = Cetacaine
Is Benzocaine (topical) an ester or amide?
Ester
Which topical has a very low toxicity due to the fact that it has SLOW absorption?
Benzocaine
What is the onset of Benzocaine (topical)?
30 seconds - 2 mins
What is the duration of Benzocaine (topical)?
5-15 mins
Which topical has a 20% concentration?
Benzocaine
Where is Benzocaine (topical) metabolized?
Plasma + some liver
What is the MRD of Benzocaine (topical)?
None
What is the pregnancy category for Benzocaine (topical)?
pregnancy = category C; lactation unknown safety
What is Benzocaine (topical) spray associated with?
Methemoglobinemia
Which topical has a very low toxicity due to the fact that it has POOR absorption?
Lidocaine
Which topical is good for those with an ester allergy?
Lidocaine
Is Lidocaine (topical) an ester or amide?
Amide
What is the onset of Lidocaine (topical)
2-10 mins
What is the duration of Lidocaine (topical)
15-45 mins
Which topical has a concentration of 2%-5%?
Lidocaine
Where is Lidocaine (topical) metabolized?
Liver
What is the MRD for Lidocaine (topical)?
MRD = 300 mg, but we use 200 mg safely
What is the pregnancy category for Lidocaine (topical)?
pregnancy = category B; small amount enters breast milk
What is Cetacaine (topical) a combination of?
Benzocaine + Butamben + Tetracaine
Is Cetacaine (topical) an ester or amide?
Ester
T/F: Benzocaine, Lidocaine, and Cetacaine are all topicals that have a very LOW toxicity
True
What is the onset of Cetacaine (topical)?
30 seconds
What is the duration of Cetacaine (topical)?
30-60 mins
What is the concentration of Cetacaine (topical)?
14% benzocaine + 2% butamben + 2% tetracaine
Where is Cetacaine (topical) metabolized?
Plasma + some liver
What is the MRD for Cetacaine (topical)?
MRD = 200 mg
What is the pregnancy category for Cetacaine (topical)?
pregnancy = category C; lactation - use caution
Topical anesthetics increase ________ __________, which increases ___________
blood levels; toxicity
T/F: The concentration of topicals are lower than injectable LA’s.
False!! They’re higher
Why do we need a higher concentration in topical anesthetics?
Must diffuse thru mucous membranes
T/F: There are NO vasoconstrictors in topicals
True
Because there are NO vasoconstrictors in topicals, there is an increased __________ __________ and therefore an increased _____________
absorption rate; toxicity
Which groups of people have an increased risk of toxicity and adverse reactions to topical?
Elderly
Children
Medically compromised
What are the toxicity and adverse reactions of topical anesthetic?
Irritation @ site
Sloughing
Taste alteration
CNS effects (excitation -> depression)
CV effects (decreased HR/BP; cardiac arrest)
T/F: The CNS and CV effects of toxicity/adverse reactions in topical anesthetic have the same signs and symptoms as in injectable LAs
True!
What are the 7 ways to avoid toxic rxns from topicals?
- Know relative toxicity of drug
- Know concentration of drug
- Use smallest volume
- Use lowest concentration
- Use least toxic drug
- Limit area of application
- Avoid sprays
What does a (+) and (-) result for the aspiration test mean?
(+) aspiration = blood entered carpule
(-) aspiration = no blood; small bubble may have entered carpule
What is aspiration test and what does it determine?
Negative pressure within a cartridge prior to injecting to determine if needle is within a blood vessel
Angled surface of the needle tip
Bevel
Diameter of a needle
Gauge
The larger the gauge, the __________ the diameter
smaller
What is the weakest part of the needle?
Hub
What does the hub + needle adaptor attach?
Attaches needle to syringe adaptor
What materials can the hub + needle adaptor be?
Plastic or aluminum
What does a plastic hub + needle adaptor allow for?
Movement to align bevel
Why is the hub + needle adaptor usually marked with ink?
For bevel location
What is the end of the needle shaft that penetrates the diaphragm of the carpule?
Carpule-penetrating end
When should the carpule-penetrating end be placed?
After carpule is loaded and the harpoon is engaged
What must remain covered until ready for use?
Needle shaft