Mood Disorders Flashcards
two major neurotransmitters involved in depression
norepinephrine and serotonin (5HT)
serotonin regulates
sleep, appetite, libido
serotonin circuit dysfunction results
poor impulse control, low sex drive, decreased appetite, disturbed regulation of body temperature and irritability
decreased levels of norepinephrine results
anergia, anhedonia, decreased concentration, diminished libido (depression)
dopamine neurons in mesolimbic system effects
play a role in reward and incentive behavior processes, emotional expression, learning processes
- especially true in melancholic states in severe MDD
beck’s cognitive theory of depression (beck’s cognitive triad)`
- negative, self-deprecating view of self
- pessimistic view of world
- the belief that negative reinforcement (or no validation for the self) will continue
automatic negative thoughts
repetitive, unintended, not readily controllable
- developed by beck
- consistent in all types of depression, regardless of clinical subtype
learned helplessness (seligman)
anxiety is initial response to stressor, but replaced by depression if person feels no control over outcome
- can explain depression in older adults, impoverished, women
biogenic amine hypothesis of depression
- caused by deficiency of monoamines (esp NE and 5HT)
monoamine
amine containing one amino group
ex: serotonin, dopamine, epinephrine, norepinephrine
receptor sensitivity hypothesis of depression
supersensitivity and upregulation
- post-synaptic neuron tries to compensate for a lack of stimulation (due to deficiency of NE & 5HT)
continuum of depression: transient
in response to life’s everyday disappointments
continuum of depression: mild
normal grief response
continuum of depression: moderate
dysthymic disorder
continuum of depression: severe
major depressive episode or disorder
major depressive episode (general description)
- often following psychosocial stressor (marital, occupational, academic problems)
- many somatic complaints
- tearful, irritable, anxious, phobias
- most serious consequence: suicide
major depressive episode (common symptoms)
- depressed mood
- anhedonia
- anxiety
- psychomotor changes
- somatic symptoms
- vegetative signs