1 Glucocorticoids

Question 1

structure

Answer 1

identical to steroids produced by adrenal cortext

Question 2

function

Answer 2

within cytoplasm rather than cell surface

Question 3

indications

Answer 3

endocrine (not our focus)

• adrenal insufficiency
• physiologic doses

NON-ENDOCRINE

• inflammatory processes
• pharmacologic doses

Question 4

glucocorticoids (names)

Answer 4

• Cortisone
• Solu-cortef (hydrocortisone)
• Depo-medrol (methylprednisolone)
• Prednisone
• Orapred (prednisolone)
• Triamcinolone
• Dexamethasone

Question 5

Cortrosyn Stimulation test

Answer 5

Measures ability of adrenal cortext to produce

• adrenocorticotropic hormone (ACTH) administered
• degree of adrenal gland stimulation is measured

Question 6

Prednisone + MOA

Answer 6

Glucocorticoid
Binds to/activates receptors in cytoplasm and nucleus
Suppression of leukocyte migration, decreased capillary permeability

Question 7

Prednisone adverse effects

Answer 7

Osteoporosis
Adrenal insufficiency
Immunosuppression
Psych stuff
PPP (polydipsia, polyuria, polyphagia)

Question 8

Prednisone considerations

Answer 8

DO NOT DISCONTINUE ABRUPTLY

AM dosing more physiologic (faster metab)

Question 9

Growth and development effects

Answer 9

Inhibits cell division
Delays healing
Retards growth of children

Question 10

Calcium metabolism effects

Answer 10

Increases bone resorption
Increases renal clearance
Suppresses bone formation
Decreased intestinal absorption of Ca and Vitamin D

Question 11

Respiratory effects

Answer 11

Not bronchodilator

Inhaled = long term control, not immediate effect (>6 hours)