MOA Flashcards
1
Q
binds to tubulin to prevent polymerization into microtubules
suppresses the expression of NF-KB, a protein responsible for cytokine production
A
colchicine, acute gout
2
Q
used for gout, start low and titrate up, this drug potentiates the immunosuppressive effects of azathioprine and 6-mercaptopurine
A
allopurinol
3
Q
2nd line for those that develop a hypersensitivity to allopurinol
no adjustment needed
possible increase in CV risk
same drug interaction as allopurinol
A
febuxostat
4
Q
URATI transporter blocker that increases the excretion of uric acid with poor efficacy in patients w/ CrCl <50 ml/min
A
probenecid
5
Q
urate oxidase enzyme that converts urate to allantoin
A
pegloticase
