MOA

Question 1

agents are that indigestible absorbing water, forming a bulk emollient that distends the colon and induces peristalsis

1st line

Answer 1

bulk forming laxatives

Question 2

faster onset than bulk forming laxatives

increases stool liquidity

2nd line

Answer 2

osmotic laxatives

• polyethylene gylcol
• lactulose and sorbitol
• magnesium citrate and magnesium sulfate

Question 3

direct stimulation of the enteric nervous system leading to enhance transport and motility

Answer 3

stimulant laxatives

• Senna
• bisacodyl

Question 4

this is a stool softener that acts as a surfactant lowering surface tension of the stool leading to softening for easier defecation

Answer 4

docusate

Question 5

this is a stool softener that draws fluid into colon for lubriucation and stimulating evacuation

Answer 5

glycerin suppository

Question 6

this is a stool softener that penetrates stool and softens it

Answer 6

mineral oil

Question 7

used for chronic constipation when all other agents are ineffective

Answer 7

colonic secretagogues

Question 8

this is a colonic secretagogues that binds to guanylate cyclase leading to enhanced chloride and bicarbonate secretion for increased water secretion and motility

Answer 8

linaclotide

Question 9

this is a colonic secretagogues that enhances Cl ion secretion into intestinal lumen for water secretion and motility

Answer 9

lubiprostone

Question 10

this is an opioid antagonist indicated for opioid induced constipation which equals mu opioid receptor antagonist

Answer 10

opioid antagonist

• methylnaltrexone
• naloxegol
• naldemidine

alvimopan
-used for postoperative ileum