HIGH YIELD III

Question 1

what are the non-biologic agents?

Answer 1

tocilizumab
anakinra
rituximab
abatacept

Question 2

what are the non TNFs reserved for?

*what is required before initiation of tx?

Answer 2

reserved for patients who fail DMARDs and biologic TNF so,

DMARD to TNF-Biologic to non-TNF biologic

*TB and hepatitis screening

Question 3

this drug depletes B cells leading to high risk of developing infection with this drug

give with MTX

BBWs:
infusion rxns
Hep B reactivation
Mucocutaneous reaction
progressive multifocal leukoencephalopathy

Answer 3

rituximab

Question 4

this drug causes GI perforation?

Answer 4

tocilizumab

Question 5

inhibits janus kinase (JAK) enzymes

same warnings and screenings need to be done as the other ones

• serious infections, lymphomas
• monitor Tb, Hep, CBC, liver fx

Answer 5

tofacitinib