HIGH YIELD Flashcards
Turner syndrome is a result of?
hypogonadism
this syndrome, as a result of hypogonadism is due to loss of part or all of an x-chromosome
- nonfunctional
- amenorrhea
- give these patients estrogen replacement therapy
turner syndrome
what is the therapy approach in hormonal therapy?
primary indications
- moderate to severe menopause symptoms
- moderate to severe vulvovaginal atrophy
hormone therapy
- estrogen only therapy
- estrogen + progesterone therapy
oral
transdermal
topicals and vaginal ring
how do SERMS work?
indications?
act as estrogen agonist/antagonist depending on the specific tissue
menopause
breast cancer
fertility
what are the examples of serms?
ospemifene bazedoxifne-conjugated estrogens raloxifene tamoxifene fulvestrant
this type of drug reduces estrogen production
examples?
aromatase inhibitors
anastrozole
letrozole
exemestane
this GnRH is indicated for early puberty, endometriosis, prostate cancer, uterine fibroids, and breast cancer
luprolide
these drugs are used when there is failure to conceive after 1 yr of unprotected sex
infertility treatment
what are the examples of infertility treatment drugs?
clomiphene (SERM)
letrazole (aromatase inhibitor)
major warning about androgens?
virilization
-idea that children can get more sexual characteristics faster so wash hands and clothes that come into contact with testosterone
androgen receptor antagonists are used for?
prostate cancer and sterilization
antiandrogens, test blockers
what are the types of androgen receptor antagonists?
bicalutamide
enzalutamide
flutamide
BEeF
- spironolactone
- potassium sparing diuretic; acne in patients
what are the indications for 5-alpha reductase inhibitors?
drugs?
warnings
for patients who failed 1st line choice for BPH which were alpha-1-antagonists
finasteride
duatasteride
avoid contact w/ pregnant women
decreases libido, cause ED, muscular weakness
what are the drugs used in erectile dysfunction?
also used for? AE?
sildenafil vardenafil tadalafil avanafil -PDE5 alprostadil -PDE1
pulmonary HTN
hypotension, men taking nitrates, caution if taking alpha-adrenergic blockers
what is significant of alprostadil?
a PDE1
causes vasodilation of the cavernosal arteries
administered via intracavernosal route or by injection
