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PHARM II > ENHANCEMENT OF GABA NT > Flashcards

ENHANCEMENT OF GABA NT Flashcards

1
Q

can be used for status epilepticus but not very preferred due to sedative properties

abusable

strong CYP3A4 inducer

preg cat D leading to heart defects

AE: sedation, abuse potential

A

phenobarbital

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2
Q

can be used for status epilepticus but again it has sedative properties so not used much, used for essential tremor

strong CYP3A4 inducer

A

primidone

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3
Q

multiple MOA
no CYP induction
preg cat D leading to cleft palate
migraine prophylaxis and weight loss

AE: cognitive dysfunction, weight loss, kidney stones

A

topiramate

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4
Q

multiple MOA
CYP inhibitor
preg cat D leading to spina bifida

most teratogenic effects

AE: hepatic failure, pancreatitis, teratogenic, SJS/TEN, aplastic anemia

A

valproic acid

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5
Q

benzodiazapam reserved for 2nd or 3rd line status epilepticus treatment

highly abused and tolerance develops w/in 3-4 months

A

clonazepam

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6
Q

also benzodiazepine that come IV, IM, rectal and good for status epilepticus

A

lorazepam, diazepam, midazolam

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PHARM II (110 decks)

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