MOA Flashcards

1
Q

agonist on GnRH receptor producing an increase in test and est that desensitize and cut off the production of LH and FSH decreasing levels of test and estrogen

A

luprolide, GnRH agonist

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2
Q

competitively binds the estrogen receptors on the hypothalamus which senses less estrogen and increases GnRH and so we have more FSH and LH section to stimulate ovarian follicles

A

clomiphene, infertility treatment

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3
Q

stimulates ovulation as a aromatase inhibitor

A

letrazole, infertility treatment

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4
Q

inhibits 5-alpha reductase inhibiting formation and decreasing levels of dihydrotestosterone; decrease prostate size and improves symptoms

A

finasteride and duatasteride, 5-alpha reductase inhibitors

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5
Q

compete for cGMP binding at the site of cGMP hydrolysis on PDE5 inhibiting the enzyme, PDE5 that breaks down cGMP

A

sildenafil, -afil; all PDE5 inhibitors

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6
Q

causes vasodilation of the cavernosal arteries

A

alprostadil, prostaglandin E1

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