MOA Flashcards
agonist on GnRH receptor producing an increase in test and est that desensitize and cut off the production of LH and FSH decreasing levels of test and estrogen
luprolide, GnRH agonist
competitively binds the estrogen receptors on the hypothalamus which senses less estrogen and increases GnRH and so we have more FSH and LH section to stimulate ovarian follicles
clomiphene, infertility treatment
stimulates ovulation as a aromatase inhibitor
letrazole, infertility treatment
inhibits 5-alpha reductase inhibiting formation and decreasing levels of dihydrotestosterone; decrease prostate size and improves symptoms
finasteride and duatasteride, 5-alpha reductase inhibitors
compete for cGMP binding at the site of cGMP hydrolysis on PDE5 inhibiting the enzyme, PDE5 that breaks down cGMP
sildenafil, -afil; all PDE5 inhibitors
causes vasodilation of the cavernosal arteries
alprostadil, prostaglandin E1