MEDS II

Question 1

reduces hepatic gluconeogenesis (reduces sugar)

improves insulin sensitivity (good because insulin resistance is part of T2D)

Answer 1

metformin

Question 2

stimulates beta cells to release insulin, insulin secretagoguse

Answer 2

sulfonylureas

Question 3

this is inhibitor is in the proximal convoluted tubule and these drugs block that, blocking reabsorption of 90% of glucose

Answer 3

SGLT-2 inhibitors

Question 4

inhibits the breakdown of GLP-1 secreted during meals, which in turn increases pancreatic insulin secretion and limits glucagon secretion

Answer 4

DPP-IV inhibitors

Question 5

enhances insulin insensitivity at muscle, liver, and fat through PPAR-y

Answer 5

thiazolidinediones

Question 6

stimulates these receptors which enhances glucose dependent insulin release, decreases glucagon secretion, and slows gastric emptying

Answer 6

GLP-1 agonists

Question 7

this is an insulin secretagogue

Answer 7

meglitinides

Question 8

tx options for hyperglycemic crisis?

Answer 8

IV fluids
bicarb
insulin
potassium

Question 9

tx options for hypoglycemic management?

Answer 9

oral glucose for mild to moderate hypoglycemia

IV Dextrose and glucagon for severe hypoglycemia