HIGH YIELD

Question 1

target uric acid for asymptomatic hyperuricemia?

if tophi present target is?

Answer 1

target uric acid <6 mg/dL

<5 mg/dL

Question 2

pharmacologic tx for asymptomatic hyperuricemia?

Answer 2

none indicated, lifestyle mods

Question 3

goals of tx for gout?

Answer 3

resolve acute attacks
resolve future attacks
prevent complications

Question 4

nonpharmacologic tx for acute gouty arthritis?

Answer 4

local ice pack

Question 5

first line pharmacological options for acute gouty arthritis?

Answer 5

NSAIDs
corticosteroids
colchicine

Question 6

after tx of acute gout gout attack what is the goal?

Answer 6

prevent recurrence by maintaining low uric acid levels

Question 7

what are the indications for initiating urate lowering therapy?

Answer 7

occurrence of 2 or more gout attacks
presence of one or more tophus
CKD
H/O urolithiasis

Question 8

what are the pharmacological tx for chronic acute gout?

Answer 8

xanthine oxidase inhibitors

• allopurinol
• febuxostat

uricosurics, 2nd line

• probenecid
• lesinurad

Question 9

what is the tx for refractory gout?

AE?

Answer 9

pegloticase

antibody to development to pegloticase leading to loss of efficacy by month 4 in observed study