MOA

Question 1

competitively antagonizes ACh from binding to Ach receptors resulting in motor weakness that progresses to total flaciid paralysis?

Answer 1

atracurium
cisatracurium
vecuronium
rocuronium
mivacurium
pancuronium

*nondepolarizing agents

Question 2

w/in 30 seconds, fasiculations from depolarization occur followed by flaccid paralysis because ACh receptors are activated and then continuous admin of this drug if pt needs it?

Answer 2

succinylcholine

*depolarizing agents

Question 3

agonist at GABAb receptors to inhibit excitatory NTs in the brain and spinal cord

what is this spasmolytic?

Answer 3

Baclofen

Question 4

what is this spasmolytic?

alpha-2 agonist like clonidine but with 1/15th the blood pressure lowering effects

Answer 4

Tizanidine

Question 5

what is this spasmolytic?

binds to skeletal muscles preventing Ca release and preventing contraction on the ryanodine receptor

Answer 5

Dantrolene

Question 6

treats acute muscle spasms from local tissue trauma or muscle strains?

Answer 6

antispasmodics

• carisoprodol
• chlorzoxazone
• cyclobenzaprine
• diazepam
• metaxalone
• methocarbamol
• orphenadrine

Question 7

affects the presynaptic membrane of the neuromuscular blocker and blocks the Ca dependent ACh vesicle from releasing into the presynaptic synapse producing a state of denervation

muscle inactivation persists

Answer 7

botulinum toxin

Question 8

these are compounds that bind to cannabinoid receptors (CB1 and CB2)

Answer 8

cannabinoids