HIGH YIELD-NSAIDS Flashcards
how do NSAIDs act?
inhibiting the prostaglandin enzymes (COXs)
what are the types of NSAIDs?
example?
most are competitive, noncompetitive, or mixed reversible inhibitors of COX
aspirin is a noncompetitive, irreversible inhibitor
NSAIDs treat?
inflammation
pain
fever
PGE2 and PGI2 mediate?
which one crosses the BBB?
inflammation and pain
PGE2
what are the COX enzymes?
COX-1
COX-2
NSAID PK elimination via?
short and long acting
adverse effects what systems?
GI CV Renal others -increased bleeding -hypersensitivity -hepatic
GI BBW?
serious-bleeding, ulcers, and perforation
inhibition of COX-1, PGI2 and PGE2 inhibit acid secretion
CV BBW?
COX-1 affects TXA2 causing vasoconstriction and platelet aggregation
MI, heart failure, stroke, HTN
COX-2 agents have a higher risk of CV toxicity
Renal AE?
affect of NSAIDs and ACE/ARB
sodium and water retention, increased BP
increases potassium levels
acute kidney injury (AKI)
-kidney loses perfusion
*NSAIDS constrict afferent arteriole, and ACE/ARB dilate the efferent arteriole
what are the warnings of NSAIDs?
NSAIDs can cross the placenta and may cause premature closure of the ductus arteriosus
what are the drug-drug interactions?
ACE inhibitors, ARBs
corticosteroids
anticoagulants
lithium w/ NSAIDs raises it levels up b/c it looks like Na and we know Na gets reabsorbed
what are the NSAIDs?
aspirin ibuprofen naproxen indomethacin ketorolac diclofenac
what are the COX-2 selective inhibitors?
celecoxib meloxicam nabumetone etodolac acetaminophen
