Methrotrexate Flashcards
Report signs of what in methotrexate?
Blood disorders
Liver toxicity
Respiratory effect
Signs of blood disorders in methotrexate?
Sore throat
Bruising
Mouth ulcers
Methotrexate toxicity antidote?
Folinic acid (Calcium folinate)
What should pt’s be cautious about while on methotrexate?
Sun - Photosensitivity
Methotrexate monitoring?
Full blood count
Renal function test
Liver function test
Methotrexate monitoring regimen periods?
Every 1-2wks until stable
Every 2-3 months thereafter
How long should contraception be used for with methotrexate?
During the treatment and At least 6 months after for both men and women
Why does pregnancy have to be screened out in methotrexate?
Methotrexate is an anti folate which can cause harm to foetal growth
What other drugs are antifolates?
Trimethoprim
Phenytoin
Co-Trimoxazole
What drugs should be avoided in methotrexate use?
Omeprazole/Esomeprazole - reduces clearance so toxicity increases
Rifampacin, antifungals - Hepatotoxic drugs
NSAIDs ibuprofen - reduces renal clearance so toxicity increases
Which OTC drug to avoid in methotrexate pt?
Ibuprofen! - reduces renal clearance so increases toxicity
MHRA Methotrexate?
Caution in sun due to photosensitivity in methotrexate
