CVD - Statins

Question 1

Night time Statins?

Answer 1

Simvastatin
Pravastatin
Fluvastatin

SPF

Question 2

Secondary prevention statin?

Answer 2

Atrovastatin 40mg - 80mg

Question 3

Before statin initiation what tests should be done?

Answer 3

Thyroid test
Hb1AC level if high risk diabetes
LFT
Renal tests & lipid profile
Creatinine kinase
Serum transamines

Question 4

When to measure LFT during statin use?

Answer 4

Before initiation, 3 months in and then at 12months

Question 5

Importance of creatine kinase test in statins?

Answer 5

Shows muscle aches if elevated

Question 6

Creatine Kinase testing what if it is over 5 times the upper limit prior to statin initiation?

Answer 6

DO NOT START STATIN

Instead retest then wait 7 days

Question 7

Creatine kinase is less than 5 times the upper limit but is raised?

Answer 7

Low dose statin can be initiated

Ensure to stay monitoring after

Question 8

At what level of serum transamines would you discontinue statin?

Answer 8

Over 3 times the upper limit

Question 9

Statins side effects?

Answer 9

Rhabdomyolis & Myopathy

Lung disease (cough? Weight loss? dyspnoea?

Teratogenic

Question 10

Statins in pregnancy?

Answer 10

AVOID IN PREGNANCY
& 3 months prior to conceiving

Question 11

Statin interactions with CYP450 inducers

Answer 11

Statins conc will decrease

Question 12

Statins interaction with CYP450 inhibitors?

Answer 12

Increase Statin plasma conc

Question 13

Statins and Macrolides use?

Answer 13

Stop and reinitiate after abx course finishes

Question 14

Statins and Fusidic acid use?

Answer 14

Stop statin use temporarily then start
7 days after last dose of Fusidic acid

Question 15

Simvastatin Max dose is 20mg with which drugs?

Answer 15

Amiodarone
Amlodopine
Diltiazem/Verapamil

Question 16

Simvastatin Max dose is 40mg with which drugs?

Answer 16

Ticagrelor

Question 17

Atorvastatin Max dose is 10mg with which drugs?

Answer 17

Ciclosporin
Tipranavir

Question 18

Fibrates side effects and risks?

Answer 18

Increase muscle side effects

Mytoxic (Muscle damage) in Renal impairment

Question 19

Fibrates monitoring?

Answer 19

Liver function test every 3 months for 1st year

Question 20

Total cholesterol levels?

Answer 20

5 or below

Question 21

HDL cholesterol healthy range?

Answer 21

1 or above

Question 22

LDL healthy range?

Answer 22

3 or Below

Question 23

Non HDL healthy range?

Answer 23

4 or below

Question 24

Triglycerides healthy range?

Answer 24

2.3 or below

Question 25

Which cholesterols are considered bad?

Answer 25

LDL OR NON-HDL