Endocrine - Diabetes Insipidus

Question 1

What is diabetes insipidus key symptoms?

Answer 1

Excess urine
Extreme thirst

Question 2

Two types of diabetes insipidus?

Answer 2

• Pituitary (Cranial)
• Nephrogenic (Partial)

Question 3

What is pituitary diabetes insipidus?

Answer 3

Lack of vasopressin (ADH) production

Question 4

Treatment for pituitary diabetes insipidus?

Answer 4

Vasopressin or Desmopressin

Question 5

What is Nephrogenic (Partial) diabetes insipidus?

Answer 5

Kidneys that do not respond to to ADH

Question 6

Nephrogenic diabetes insipidus treatment?

Answer 6

Thiazides - paradoxical effect (opposite)

Question 7

Why Desmopressin instead of vasopressin?

Answer 7

Desmopressin more potent and last longer than vasopressin.

No vasoconstrictor effect

Question 8

Side effects of Desmopressin?

Answer 8

• Hyponatraemia (CDDS)
• Nausea

Question 9

If there is too much ADH what happens?

Answer 9

Too much water is stored, salt dilutes therefore Hyponatramia

Question 10

Treatment of Too much ADH?

Answer 10

1) Fluid restriction
2) Democlocycline
3) Tolvaptan (Vasopressin antagonist)

Question 11

Democlocycline work in too much Adh secretion?

Answer 11

Blocks renal tubular effect of ADH,
Allowing more water to be excreted

Question 12

Why avoid rapid correction of Hyponatraemia with Tolvaptan?

Answer 12

Can lead to osmotic demyelination ( serious neurological event)