CVD - Diuretics

Question 1

Thiazides - how do they work?

Answer 1

They inhibit sodium Reabsorption at DVT

Question 2

When to give Thiazides?

Answer 2

Early in the day to avoid sleep problems

Question 3

Thiazide and Loop diuretics electrolyte imbalances and other imbalance?

Answer 3

Hypokalaemia
Hyponatraemia
Hypomagnesaemia
Hypotension

Question 4

What diuretic exacerbated diabetes/Gout?

Answer 4

Loop & Thiazides

Question 5

How long do thiazides last and why’s that good?

Answer 5

24 hrs so best to take early in the day - reduces elderly fall

Question 6

How long do Loop diuretics last?

Answer 6

6 hours so given BD (avoids sleep interference)

Question 7

Loop diuretics mechanism of action?

Answer 7

Inhibit reabsorption of sodium, potassium and chloride at loop of henle

Therefore causes hypokalaemi, Hyponatraemia

Question 8

Loop diuretics mechanism of action?

Answer 8

Inhibit reabsorption at loop of henle

Question 9

Potassium sparing diuretics mechanism of action?

Answer 9

Prevents sodium reabsorption at DVT collecting duct and helps retain potassium

Therefore sodium lost = Hyponatraemia
Potassium retained = Hyperkalaemia

Question 10

Specific group of potassium sparing diuretics which is the class spiralactone is from?

Answer 10

Aldosterone Antagonists

Question 11

What colour urine does Potassium sparing diuretics cause?

Answer 11

Blue urine

Question 12

Two other side effects of potassium sparing diuretics to know?

Answer 12

Libido change & Breast pain tenderness

Question 13

Spironlactone/loop diuretics interaction with Lithium?

Answer 13

It Reduces lithium secretion

Question 14

Loop & Aminoglycosides interactions?

Answer 14

Nephrotoxicity & Ototoxicity

Question 15

Which diuretics cause hypokalaemia?

Answer 15

Loop & Thiazides

Question 16

Which diuretics cause Hyperkalaemia?

Answer 16

Potassium sparing diuretics