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PRP2 > Immunosupression > Flashcards

Immunosupression Flashcards

1
Q

TPMT enzyme does what?

A

Inhibits repairment and making of DNA

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2
Q

Why pre screen for TPMT levels?

A

To avoid under active TPMT leading to Myelosuppression

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3
Q

Azathioprine report what?

A

Sore throat, Bruising, Bleeding

Neutropenia and Thrombocytopenia

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4
Q

What side effect is common at start of Azathioprine use?

A

Nausea

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5
Q

Other common side effect of Azathioprine?

A

Hypersensitivity Reactions

Malaise
Fever
Rash
Hypotension
Myalgia

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6
Q

Monitor what for Azathioprine?

A

TPMT levels (enzyme)

Liver function test

FBC - first 4 weeks then atleast every 3 months

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7
Q

2 key interactions with Azathiprine?

A

Ace inhibitors - Haematological toxicity

Allopurinol - Anaemia/Leucopenia

AVOID USE TOGETHER

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8
Q

Ciclosporin prescribed by?

A

Brand name

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9
Q

Ciclosporin causes hyper and hypo what?

A

Hyperglycaemia, Hyperkalaemia, Hyperuricaemia, Hyperlipidaemia, Hypertension

+ ONLY Hypomagnesium

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10
Q

Ciclosporin can also cause what condition that CCB’s also cause?

A

Ginger Hyperplasia

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11
Q

Visual disturbances can be caused by which immunosuppressive drug?

A

Ciclosporin topical

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12
Q

Purple Grape fruit juice and Ciclosporin?

A

Decreases Ciclosporin exposure

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13
Q

Grapefruit + Pomelo juice and Ciclosporin?

A

Increase Ciclosporin exposure

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14
Q

Ciclosporin monitor?

A

LFT
MAGNESIUM!
Blood pressure
Potassium
Lipids
Crcl

MONITOR TROUGH LEVELS! (Lowest level of drug in pt body)

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15
Q

Ciclosporin counselling?

A

Avoid Expisure to UV light /Sunlight

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16
Q

Tacroliumus side effects?

A

Hyperglycaemia, Hyperkalaemia, Hypertension, Hyperuricaemia

Hypotension

Blood Dyscrasia

Visual disturbances

CVD - QT PROLONGATION , Cardiomyopathy

Nervous system , peripheral neuropathy

17
Q

Tacrolimus interacts with what?

A

Grapefruit juice + Pomelo + Pomegranate

DO NOT USE if hypersensitive to Macrolides

18
Q

Tacrolimus monitor?

A

LFT
GLUCOSE LEVELS
ELECTROLYTES
ECG
CrCl

19
Q

Mycophenolate side effects?

A

Bone marrow suppression

Pure red cell aplasia

Hypogammaglobulinaemia

Bronchiectasis

20
Q

Hypogammaglubulinaemia - what would you have to do?

A

Measure immunoglobulin levels in recurrent infections

21
Q

When to consider if or taking mycophenolate pt has Bronchiectasis?

A

SOB
COUGH

22
Q

Mycophenolate MHRA warnings?

A

Teratogenic

Women - contraception during + 6wks after

Men - Contraceptiin during + 90 days after (for partner as well)

23
Q

In the case of Pure red cell aplasia in Mycophenolate - what should be done?

A

Reduce dose or discontinue

24
Q

Mycophenolate Mofetil works by?

A

Inhibiting purine synthesis

25
Q

Bone marrow suppression - What you expect to see symptoms wise ?

A

Sore throat, bruising , bleeding

PRP2 (74 decks)

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