Livestock Breeding Cycles Flashcards
GnRH
: Gonadotrophin releasing hormone;
FSH:
Follicle stimulating hormone;
LH:
Luteinising hormone;
ABP
: Androgen-binding protein;
Follicular Phase
• GnRH secreted from hypothalamus in a pulsatile manner
• Stimulates release of follicle stimulating hormone (FSH) and pulsatile luteinising
hormone (LH)
• FSH binds to FSH-R on granulosa cells of follicle
• Increased follicular growth and development
• LH binds to LH-R on theca cells stimulating androstenedione synthesis
• Androstenedione diffuses to granulosa cells and is converted to oestrogen (oestradiol 17b) under the influence of FSH
- Growing (dominant follicle) secretes inhibin • Negative feedback at pituitary
- Inhibits release of FSH
- Ensures small follicles do not mature
- Oestradiol stimulates GnRH and LH secretion (positive feedback loop)
- Oestradiol levels surge peaking on day 0 of cycle and causing oestrus behaviour
Ovulation
- Rising oestradiol concentrations increase LH pulse frequency
- 1 pulse every 75 min at start of follicular phase
- 1 pulse every 45 min on day 0 of oestrous cycle
- Oestradiol peak causing a surge in LH concentrations (the LH surge)
- Lasts approx. 12 h
- Induces ovulation (timing dependent on species)
- Granulosa and theca cells luteinise to form the large and small cells of the corpus luteum respectively
Luteal Phase
• LH binds to LH-R on small cells of corpus luteum stimulating the synthesis of progesterone.
• Progesterone acts at hypothalamic-pituitary axis to suppress LH pulse frequency though LH pulse amplitude increases.
• Low frequency, high amplitude LH stimulate further progesterone secretion. • Large luteal cells synthesis progesterone in absence of an LH stimulus, and
progesterone concentration steadily increase to a max on day 8-10 of cycle.
- Progesterone binds to progesterone receptors in uterine endometrium and myometrium
- Preparation of uterine environment for pregnancy
- Proliferation of endometrium
- Increased secretory activity
- Increased endometrial vasculature
Luteolysis
• Progesterone remains high until regression of the corpus luteum
Luteolysis (also known as luteal regression) is the structural and functional degradation of the corpus luteum (CL), which occurs at the end of the luteal phase of both the estrous and menstrual cycles in the absence of pregnancy.
Bovine. Reproductive cycle
Polyoestrous
Bovine Length of Oestrus (hours)
18
Bovine Gestation Length (days) (average)
279-290 (283)
Ovine Reproductive cycle
Seasonal Polyoestrous
Ovine Length of Oestrous cycle (days) (range)
17 (16-17)
Ovine Gestation Length (days) (average)
145-152 (147)
Porcine Reproductive cycle
Polyoestrous
Porcine Length of Oestrus
36-96
Porcine Gestation Length (days) (average)
111-120 (115)
Caprine Reproductive cycle
Seasonal Polyoestrous
Caprine Length of Oestrous cycle (days) (range)
21 (19-21)